Long-term health of people who had childhood cancer
Follows adults who had childhood cancer to study late health effects of treatment.
Plain-language title generated from the registry record
Registry title: Childhood Cancer Survivor Study
Key facts
- Where
- Toronto, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people who survived five years after childhood or young-adult cancer diagnosed before age 21. It also includes siblings as a comparison group.
- Age
- Cancer diagnosed before age 21 years; the record gives no age range for joining now.
- Sex
- All sexes can join.
- Disease stage
- Five-year survival after leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor or kidney tumor, neuroblastoma, soft tissue sarcoma or rhabdomyosarcoma. Diagnosed between January 1, 1970 and December 31, 1999 at a participating centre.
Main reasons for not taking part
- Non-malignant tumors treated with radiation and/or chemotherapy (for example Langerhans cell histiocytosis, meningioma, craniopharyngioma)
- Does not speak English or Spanish
- Lived outside the US or Canada at the time of diagnosis
Read by machine on 12 November 2026.
Where in Canada
- The Hospital for Sick ChildrenToronto, CanadaContact: Paul Nathan, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- St. Jude Children's Research Hospital
- Trial code
- NCT01120353
- Record updated
- 17 June 2026
- Original description
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.Read full original descriptionShow less
Childhood Cancer Survivor Study
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Inclusion: Initial Cohort:; Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers; Expanded cohort:; Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers; English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
Exclusion: Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy; For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location; Non-English speaking or residence outside the US or Canada; Sibling Controls:.