Tests whether physical activity improves insulin resistance in older adults with obesity
Tests physical activity in older adults who are obese or inactive.
Plain-language title generated from the registry record
Registry title: Age and Insulin Resistance
Key facts
- Where
- Bern and Lausanne, SwitzerlandSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Source: NCT01224886, who can take part
Where in Switzerland
- University of BernBern, SwitzerlandNo longer taking part
- UNIL and CHUVLausanne, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Lausanne
- Trial code
- NCT01224886
- Record updated
- 5 December 2024
- Original description
Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the risk for type 2 diabetes and is a key feature of the metabolic syndrome. The elevated prevalence of obesity and type 2 diabetes in the older population has important consequences on the morbidity and mortality as well as on the economic burden on society. Controversy currently exists as to whether or not aging contributes to insulin resistance. Many potential factors confound the association between aging and insulin resistance, including obesity and physical inactivity.Read full original descriptionShow less
In French AGIR Means to Get Into Action. This is the Generic Title of Our Study.
Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the risk for type 2 diabetes and is a key feature of the metabolic syndrome. The elevated prevalence of obesity and type 2 diabetes in the older population has important consequences on the morbidity and mortality as well as on the economic burden on society. Controversy currently exists as to whether or not aging contributes to insulin resistance. Many potential factors confound the association between aging and insulin resistance, including obesity and physical inactivity.
Ectopic lipid depositions, defined as an excess accumulation of triglycerides in non adipose tissues such as in the liver (intrahepatic lipids) and within the muscle fibers (intramyocellular lipids), are positively associated with obesity and insulin resistance. Furthermore, the accumulation of intracellular lipids is often cited as being a key determinant in the underlying mechanisms of insulin resistance. In addition of playing an important role in obesity and type 2 diabetes, these ectopic fat depositions are also observed in common conditions such as aging and physical inactivity.
The intervention trial will test in skeletal muscle, liver and heart of sedentary obese volunteers, normal weight volunteers and masters athletes, the overall hypotheses that exercise improvement of fat oxidation capacity and/or decrease of damaging fat metabolites is a primary factor that predicts the improvement in insulin resistance.
Inclusion: Age 60-80; Sedentary or highly trained; BMI 18-40; Non-Smoker; Normal glucose tolerance or impaired glucose tolerance; Willingness to comply with the protocol.
Exclusion: Recent hormone replacement therapy; Contraindication to moderate exercise or clinical conditions precluding from joining an exercise program, such as clinically significant cardiovascular disease, peripheral vascular disease, uncontrolled hypertension, neurological or orthopedic disease; Known diabetes; Severe anemia or lipid disturbances, hepatic or renal disease; Recent history of cancer; Known allergy to lidocaine or other local anesthetic; Known drugs to affect glucose homeostasis such as nicotinic acid, glucocorticoids; Recent weight loss or weight gain; Hypothyroidism; Positive stress test; Active alcohol or substance abuse.