Studying genes and environment to understand who may develop multiple sclerosis
Studies genetic, environmental and immune factors that may raise risk of multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Genes and Environment in Multiple Sclerosis
Key facts
- Where
- Bethesda, Boston, New York, and Pittsburgh, United StatesSee the 5 sites
Where in United States
- National Institute of Neurological Disorders and StrokeBethesda, United StatesTaking people
- Brigham and Women's HospitalBoston, United StatesNo longer taking part
- Massachusetts General HospitalBoston, United StatesNo longer taking part
- Columbia University Irving CenterNew York, United StatesTaking people
- University of PittsburghPittsburgh, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Columbia University
- Trial code
- NCT01353547
- Record updated
- 14 May 2026
- Original description
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.Read full original descriptionShow less
Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.
Inclusion: First Degree Relatives of Patients with MS, or; Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or; Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS; Live in the United States.
Exclusion: Does not match any of the inclusion criteria.