Studying how bariatric surgery affects insulin and energy in obesity
Studies how weight-loss surgery changes insulin sensitivity in adults with obesity and diabetes.
Plain-language title generated from the registry record
Registry title: The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
Key facts
- Where
- Düsseldorf, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 70 years old?
Source: NCT01477957, who can take part
Where in Germany
- German Diabetes CenterDüsseldorf, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- German Diabetes Center
- Trial code
- NCT01477957
- Record updated
- 10 January 2025
- Original description
The purpose of this study is:Read full original descriptionShow less
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism in Obesity Grade 2 -3
The purpose of this study is:
1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2. To explore to what extent hepatic and muscular disorders of energy metabolism occur in patients with obesity (degree 2-3) 3. To explore whether the steato liver occurring in patients with obesity (degree 2-3) is associated with the degree of liver inflammation
Inclusion: Aged ≥ 20 years- ≤ 70 years; BMI 20- 25 kg/m 2 normal- weight group; BMI 35- 39,9 kg/m 2 (Obesity grade 2); BMI >40 kg/m 2 (Obesity grade 3).
Exclusion: Acute illness 2 weeks before start of examination; Pharmacological- immunotherapy (Cortisol, Antihistaminika, ASS); Glitazone Therapy; Smoking cigarettes, Alcohol- and drug abuse; Autoimmune or Immune disorder diseases (Leukozyten < 5000/µl; Heart disease, condition after heart attack; Thyroid disorders; Psychiatric disorders; Risk for/ or diagnosed HIV/ AIDS or Hepatitis B/C; Liver disease, which are not caused by non- alcoholic steato- hepatitis; Impaired wound healing or clotting disorders; Allergic reaction to local anesthetics; Malignant cancer; Renal insufficiency (Kreatin > 1,5 mg/dl); Anemia (Hb <12g/l, controlled before every day of examination) or blood donations 4weeks before examination; Participation in another trial within the last 2 weeks; Pregnancy, Lactation, Menstruation; Working on night shifts or irregular rhythm of night- day.