Studies how a brain area controls movement in Parkinson's disease
Studies brain stimulation of the subthalamic nucleus in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Subthalamic Nucleus, Akinesia and Parkinson's Disease
Key facts
- Where
- Paris, FranceSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 70 with Parkinson's disease, some already operated with deep brain stimulation, and also healthy volunteers.
- Age
- 18 to 70 years
- Sex
- All sexes
- Disease stage
- Idiopathic Parkinson's disease. Patients to be operated have motor fluctuations or dyskinesias despite optimum treatment. Non-operated patients have gait or balance problems not improved by treatment.
- Earlier treatment
- Patients to be operated must respond very well to levodopa (more than 50% UPDRS motor score improvement in the acute test). Already-operated patients must have had bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year.
Main reasons for not taking part
- Dementia (MMS<24/30)
- Psychiatric illness that is getting worse
- Contraindication to MRI (for example pacemaker, metal implants, pregnancy, claustrophobia)
- Persons under guardianship, curatorship or other deprivation of rights
- Healthy volunteers: neurological, orthopedic or psychiatric history
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT01682668, who can take part
Where in France
- CIC-GHPSParis, FranceContact: Marie-Laure WELTER, PHTaking people
- Groupe Hospitalier Pitie - SalpetriereParis, FranceContact: Marie-Laure Welter, MD, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Institut National de la Santé Et de la Recherche Médicale, France
- Trial code
- NCT01682668
- Record updated
- 7 July 2026
- Original description
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .Read full original descriptionShow less
Role of the Subthalamic Nucleus in the Control of Movement: Physiopathology of Akinesia in Parkinson's Disease.
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN stimulation improves motor signs in PD patients .
Inclusion: Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank); Age between 18 and 70; Motor complications in the form of fluctuations in motor state or dyskinesias induced by dopaminergic therapy, despite medical treatment optimum; Other medical conditions that are stable or do not interfere with the procedure proposed; Excellent responsiveness to levodopa (UPDRS motor score improvement greater than 50% in the acute levodopa test); Brain MRI without abnormality; Normality of biological examinations; Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent); Patient with social health insurance; Criteria for non-inclusion of Parkinsonian patients who will be operated; Contraindication to examinations necessary for inclusion; Evolutionary psychiatric pathology; Dementia(MMS<24/30); Patients with a medical condition that makes surgery dangerous neuro-surgical; Bleeding-promoting diseases and laboratory test abnormalities clotting; Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia); Taking drugs interfering with coagulation for 1 month before intervention; Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty; Selection criteria for non-operated patients; Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank); Age between 18 and 70; Other medical conditions that are stable or do not interfere with the proposed protocol; Presence of axial signs (gait and/or balance disorders) no improved by antiparkinsonian treatment; Brain MRI without notable abnormality; Normality of biological examinations; Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent); Patient with social health insurance; Criteria for non-inclusion of non-operated patients; Contraindication to examinations necessary for inclusion; Progressive psychiatric pathology; Dementia (MMS<24/30); Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia); Persons under guardianship, curatorship or any other administrative or judicial measuredeprivation of rights and liberty; Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank); Bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year; Age between 18 and 70; Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent); Patient with social health insurance; Criteria for non-inclusion of Parkinsonian patients (already operated); Contraindication to examinations necessary for inclusion; Evolutionary psychiatric pathology; Dementia(MMS<24/30); Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty; Age between 18 and 70 years old; Normal neurological examination; Person who voluntarily and informedly agreed to participate in the study (signature of a written consent); Patient with social health insurance; Criteria for non-inclusion of healthy subjects; Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights and freedom; Existence of neurological, orthopedic or psychiatric history; Existence of contraindications to MRI (cardiac or neural pacemaker, ferromagnetic surgical clips, implants and metallic objects, foreign bodies intraocular, pregnancy, claustrophobia).