Checks inherited gene variants in families using saliva samples
Tests a saliva genetic kit to classify gene variants in families with cancer risk.
Plain-language title generated from the registry record
Registry title: COsegregation of VARiants in Panel of Genes
Key facts
- Where
- Fort-de-France, MartiniqueSee the site
Where in Martinique
- CHU de Fort de FranceFort-de-France, MartiniqueTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institut Curie
- Trial code
- NCT01689584
- Record updated
- 1 September 2026
- Original description
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.Read full original descriptionShow less
Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Inclusion: Index cases:; A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned; Age ≥ 18 years; Signed written inform consent "index case"; Related parties:; Any relative of an index case with cancer; Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case; For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care; Age ≥ 18 years; Information and signature of the informed consent "selected relatives".
Exclusion: Minors; Persons deprived of liberty or under guardianship (including curators); Absence of signed written inform consent.