Checks inherited gene variants in families using saliva samples
Tests a saliva genetic kit to classify gene variants in families with cancer risk.
Key facts
- Who runs it
- Institut Curie
- Where
- Noumea, New CaledoniaSee the siteAlso in 4 other countries, 61 sites
- Trial code
- Registry title
- COsegregation of VARiants in Panel of Genes
- Status
- Recruiting
- People taking part
- 11,000 people, planned
- Started
- 2 Jul 2012
- Expected to end
- 2 Jan 2038
- Type of study
- Interventional
- Treatments tested
- salivary kit
- Record updated
- 1 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who carry a certain gene variant found in a cancer genetics test, and for their relatives with or without cancer.
- Age
- 18 years or older
- Sex
- All sexes can join
- Biomarker or test result
- Index cases carry a gene variant of class 3, 4 or hypomorphic class 5 chosen by the national expert group. Relatives of class 4 or hypomorphic class 5 variants may already have a test result for the variant.
Main reasons for not taking part
- Minors
- People deprived of liberty or under guardianship, including curators
- People without signed written informed consent
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Index cases:
- A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned
- Age ≥ 18 years
- Signed written inform consent "index case"; Related parties:
- Any relative of an index case with cancer
- Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case
- For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care
- Age ≥ 18 years
- Information and signature of the informed consent "selected relatives"
Who cannot take part
- Minors
- Persons deprived of liberty or under guardianship (including curators)
- Absence of signed written inform consent
Where in New Caledonia
Also in 4 other countries, 61 sites
- Centre Hospitalier Territorial Gaston BourretNoumea, New CaledoniaContact: Catherine CHARLIER, MDNot yet recruiting
About the trial
What the trial wants to find out
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
The group in the trial
- CovarOther group
Treatment: salivary kit
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling
- Plain-language title
- Checks inherited gene variants in families using saliva samplesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 1 September 2026