Checks inherited gene variants in families using saliva samples
Tests a saliva genetic kit to classify gene variants in families with cancer risk.
Plain-language title generated from the registry record
Registry title: COsegregation of VARiants in Panel of Genes
Key facts
- Where
- Saint-Pierre, RéunionSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who carry a certain gene variant found in a cancer genetics test, and for their relatives with or without cancer.
- Age
- 18 years or older
- Sex
- All sexes can join
- Biomarker or test result
- Index cases carry a gene variant of class 3, 4 or hypomorphic class 5 chosen by the national expert group. Relatives of class 4 or hypomorphic class 5 variants may already have a test result for the variant.
Main reasons for not taking part
- Minors
- People deprived of liberty or under guardianship, including curators
- People without signed written informed consent
Read by machine on 12 November 2026.
Where in Réunion
- CHU Sud Réunion Saint-PierreSaint-Pierre, RéunionContact: Hanitra RANJATOELINA, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Institut Curie
- Trial code
- NCT01689584
- Record updated
- 1 September 2026
- Original description
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.Read full original descriptionShow less
Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Inclusion: Index cases:; A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned; Age ≥ 18 years; Signed written inform consent "index case"; Related parties:; Any relative of an index case with cancer; Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case; For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care; Age ≥ 18 years; Information and signature of the informed consent "selected relatives".
Exclusion: Minors; Persons deprived of liberty or under guardianship (including curators); Absence of signed written inform consent.