Imaging Tests for Detecting and Tracking Glaucoma Over Time
Studies eye imaging tools to detect glaucoma early and predict how it progresses.
Plain-language title generated from the registry record
Registry title: Functional and Structural Imaging for Glaucoma
Key facts
- Where
- Portland, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 85 years old?
Source: NCT01957267, who can take part
Where in United States
- Oregon Health & Science University: Casey Eye InstitutePortland, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Oregon Health and Science University
- Trial code
- NCT01957267
- Record updated
- 9 September 2026
- Original description
The specific aims of the clinical studies are to:Read full original descriptionShow less
Longitudinal Observational Study Using Functional and Structural Optical Coherence Tomography to Diagnose and Guide Treatment of Glaucoma
The specific aims of the clinical studies are to:
* Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.
Inclusion: No history or evidence of retinal pathology or glaucoma; Normal Humphrey 24-2 VF: A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%); Intraocular pressure < 21 mm Hg; Central corneal pachymetry > 500 microns; No chronic ocular or systemic corticosteroid use; Open angle (gonioscopy must show 75% or more of the angle to be Grade 2 or more by Shaffer's grading system); Normal appearing ONH and NFL: vertical and horizontal cup/disc ratio (CDR) ≤ 0.5 and intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect; Symmetric ONH between left and right eyes: CDR difference < 0.2 in both vertical and horizontal dimensions; ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:; diffuse or localized thinning of the rim; disc (splinter) hemorrhage; notch in the rim; vertical cup/disc ratio greater than the fellow eye by > 0.2; Presence or absence of VF defects as measured by Humphrey SITA 24-2 VF.
Exclusion: Previous intraocular surgery except for uncomplicated keratorefractive surgery and cataract extraction with posterior chamber intraocular lens implantation; Other diseases that may cause VF loss or optic disc abnormalities; Life-threatening or debilitating illness making it unlikely patient could successfully complete the study; Age < 40 or >85 years; Best-corrected visual acuity less than 20/40; Refractive error of > +3.00 D or < -7.00 D; Diabetic retinopathy; Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil; Inability to perform reliably on automated VF testing; Refusal of informed consent or of commitment to the full length of the study.