Collects tumor samples from adults with lung and thymic cancers
Gathers tumor tissue and health information from adults with lung and thymic cancers.
Plain-language title generated from the registry record
Registry title: Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors
Key facts
- Where
- Bethesda, United StatesSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with lung cancer or thymic cancer. It collects tissue samples to study these cancers.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Non-small cell lung cancer, small cell lung cancer, extrapulmonary small cell cancer, pulmonary neuroendocrine tumors or thymic epithelial tumors, confirmed under the microscope. People without a final diagnosis can also join if a cancer of these types is clinically likely.
Main reasons for not taking part
- Active major organ disease that would raise the risk of a biopsy, such as ischemic heart disease, recent heart attack, active heart failure or lung dysfunction
- Active medical or psychological illness that may raise the risk, at the investigator's discretion
- Known HIV-positive people who are not on combination antiretroviral therapy
- Children under 18
- People who cannot understand or sign the written consent form
Read by machine on 9 November 2026.
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT02146170
- Record updated
- 16 October 2026
- Original description
Background:Read full original descriptionShow less
Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors
Background:
- Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year. Researchers want to gather tissue samples from people with lung and thymic cancers to understand the disease better. This may lead to new ways to diagnose and treat it.
Objective:
- To collect tissue samples for use in the study of lung cancers.
Eligibility:
- Adults over age 18 with non-small cell lung cancer, small cell lung cancer, extra pulmonary small cell cancer, pulmonary neuroendocrine tumors, and thymic epithelial tumors.
Design:
* Participants will be screened with a medical history, physical exam, and blood tests. They will be asked about how they perform their daily tasks. * Participants may be asked to give urine and blood samples. They may give a saliva sample if they cannot give blood. They will also give a sample of their tumor from a biopsy they had. They may also be given the option to undergo a biopsy. * Participants may have MRI, CT, and/or PET scans of the body. They will lie in a machine that takes pictures of the body. * After visits to the Clinical Center end, researchers will contact participants by phone every year to check on their health.
Exclusion: Active concomitant medical or psychological illnesses that may increase the risk to the subject, at the discretion of the Principal Investigator; Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction; Known HIV-positive individuals not on combination antiretroviral therapy are ineligible.
INCLUSION CRITERIA:; Individuals with histologically or cytologically confirmed NSCLC, SCLC, ESCC, PNET, and TET; Individuals consulted in the Clinical Center without a definitive diagnosis, but clinically considered likely to have a malignancy of the above histologies, pending further tissue acquisition and/or pathology review; Age greater than or equal to18 years. Children are excluded from the study, as the above thoracic malignancies are rare in this population; Ability of subject to understand and the willingness to sign a written informed consent document.