Tests focused ultrasound pulses for temporal lobe epilepsy in adults
Tests focused ultrasound pulses to stimulate or calm brain activity in people with epilepsy.
Plain-language title generated from the registry record
Registry title: Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy
Key facts
- Where
- Los Angeles, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT02151175, who can take part
Where in United States
- UCLALos Angeles, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- BrainSonix Inc.
- Trial code
- NCT02151175
- Record updated
- 6 August 2024
- Original description
We intend to use focused ultrasound to stimulate or suppress brain activity in patients with epilepsy. We hypothesize that focused ultrasound is capable of brain stimulation or suppression visible with functional MRI, and will not cause tissue damage.Read full original descriptionShow less
LIFUP for Treatment of Temporal Lobe Epilepsy
We intend to use focused ultrasound to stimulate or suppress brain activity in patients with epilepsy. We hypothesize that focused ultrasound is capable of brain stimulation or suppression visible with functional MRI, and will not cause tissue damage.
Inclusion: Subjects with clinical evidence from their diagnostic evaluations of unilateral hippocampal dysfunction and epileptogenicity; Subjects with seizures that have been refractory to treatment with at least three currently marketed antiepileptic drugs; Subjects with epilepsy who would clearly benefit from surgical intervention; Subjects who have been offered a non-dominant anterior-mesial temporal lobe resection as treatment for medication refractory epilepsy.
Exclusion: Subjects who have experienced status epilepticus during the 3-week baseline period prior to the operation; Subjects with a cognitive or psychiatric disorder that limits the ability to give informed consent or are unable to cooperate with the testing; Subjects with dementia, delirium and psychotic symptoms. - Subjects with ferromagnetic materials in the head; Subjects with severe cardiac disease, increased intracranial pressure, or a TENS unit; Subjects who exhibit primary generalized seizures or pseudoseizures; Subjects who have seizures secondary to drugs, alcohol, metabolic illness or progressive degenerative disease; Subjects (females) who are pregnant.