Measuring the hidden HIV reservoir in people with HIV in Uganda
Studies HIV hidden in the blood of Ugandan adults whose HIV is under control.
Plain-language title generated from the registry record
Registry title: Quantitative Measurement and Correlates of the Latent HIV Reservoir in Virally Suppressed Ugandans
Key facts
- Where
- Kalisizo, UgandaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 49 years old?
Source: NCT02154035, who can take part
Where in Uganda
- Rakai Health Sciences Program Uganda Virus Research InstituteKalisizo, UgandaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Institute of Allergy and Infectious Diseases (NIAID)
- Trial code
- NCT02154035
- Record updated
- 16 October 2026
- Original description
Background:Read full original descriptionShow less
Quantitative Measurement and Correlates of the Latent HIV Reservoir in Virally Suppressed Ugandans
Background:
Human Immunodeficiency Virus (HIV) is the virus that causes AIDS. HIV can hide in the blood for many years, even in people who have their HIV infection under control. HIV that is hiding in the blood is called the "latent HIV reservoir." Researchers want to find out more about it in this study. This knowledge may help them develop new ways to prevent or control HIV. This study will draw its participants from the Rakai Health Sciences Program in rural southwestern Uganda.
Objective:
- To measure and learn about the latent HIV reservoir in Ugandans with HIV.
Eligibility:
- Men and women at least 18 years of age with HIV.
Design:
* Participants will have a medical history and physical exam. Their medical records will be reviewed. Researchers will ask participants about their health and recent illnesses. Participants able to get pregnant will have their urine tested for pregnancy. * Participants will have their finger pricked to see if they have enough red blood cells to be eligible for the study. * If eligible, participants will have blood drawn through a needle in the arm. Their blood will also be tested for other diseases. * After the blood draw, participants will be asked to stay seated or lying down if they are not feeling well for up to 30 minutes.
Exclusion: Any condition deemed by the investigators to be a contraindication to study participation including active, serious infections (other than HIV infection) during the 2 weeks prior to enrollment; Therapy with systemic steroids, immunosuppressants or immunomodulating agents; Current use of medications which could affect clotting; Malignancies of any kind (e.g., Kaposi's sarcoma); Coagulation defects or other serious bleeding disorders; Women who are pregnant will be excluded as the required blood draw may cause anemia and because of perturbations due to hormonal or immunosuppressive states that could impact the reservoir; Inability to follow study instructions or to provide informed consent.
INCLUSION CRITERIA:; At least 18 years of age; Hemoglobin >11g/dL as assessed by fingerstick rapid test; Weight >40 kilograms; A historical diagnosis of HIV infection as indicated by any positive serological test (ELISA, HIV rapid test, or Western Blot); Virally suppressed as defined as at least two historical viral loads <40 copies/ml obtained between 10-18 months apart, and no intervening detectable viral load result >= 40 copies/ml obtained during this period; Most recent historical viral load result obtained within a year prior to the screening visit; Willingness to undergo genetic testing.