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NCT02327845Active, not recruiting

Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Source: ClinicalTrials.gov · Last updated 15 Jun 2026

Brief summary (registry, in English)

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Status (registry)
Active, not recruiting
Study type
Observational
Enrollment
708 (actual)
First submitted
24 Dec 2014
Start date
Apr 2015
Primary completion date
Jul 2031
Lead sponsor
University of Miami
NCT number
NCT02327845

What you commit to

  • Study type: Observational
  • Participants enrolled: 708
  • From Apr 2015 to the primary completion date, Jul 2031
  • 15 sites in 3 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Affected with end or late stage disease.
  • A condition or situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol. This includes (but is not limited to) neurological, psychological and/or medical conditions.

Who the study is looking for

  • Member of at least one of the following categories:
    • Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial).
    • Family member of an enrolled affected individual.
  • Able and willing to comply with relevant procedures.

Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (15)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Eberhard Karls University of Tübingen
Coordinator of this site? Confirm its status		TübingenGermanyUnknown status
University of Virginia (UVA)
Coordinator of this site? Confirm its status		CharlottesvilleUnited StatesUnknown status
Cleveland Clinic
Coordinator of this site? Confirm its status		ClevelandUnited StatesUnknown status
University of Texas Southwestern (UTSW)
Coordinator of this site? Confirm its status		DallasUnited StatesUnknown status
University of Iowa
Coordinator of this site? Confirm its status		Iowa CityUnited StatesUnknown status
Kansas University Medical Center (KUMC)
Coordinator of this site? Confirm its status		Kansas CityUnited StatesUnknown status
University of Miami
Coordinator of this site? Confirm its status		MiamiUnited StatesUnknown status
Twin Cities ALS Research Consortium
Coordinator of this site? Confirm its status		MinneapolisUnited StatesUnknown status
Stanford University
Coordinator of this site? Confirm its status		Palo AltoUnited StatesUnknown status
University of Pennsylvania
Coordinator of this site? Confirm its status		PhiladelphiaUnited StatesUnknown status
University of Texas Health Science Center San Antonio (UTHSCSA)
Coordinator of this site? Confirm its status		San AntonioUnited StatesUnknown status
University of California, San Diego (UCSD)
Coordinator of this site? Confirm its status		San DiegoUnited StatesUnknown status
California Pacific Medical Center (CPMC)
Coordinator of this site? Confirm its status		San FranciscoUnited StatesUnknown status
Wake Forest University
Coordinator of this site? Confirm its status		Winston-SalemUnited StatesUnknown status
University of Cape Town
Coordinator of this site? Confirm its status		Cape TownSouth AfricaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.