Imaging Lung Structure and Function in People With Asthma
Uses special gas MRI scans to study lungs of adults with asthma.
Plain-language title generated from the registry record
Registry title: Structure and Function MRI of Asthma
Key facts
- Where
- London, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT02351141, who can take part
Where in Canada
- Robarts Research Institute; The University of Western Ontario; London Health Sciences CentreLondon, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Dr. Grace Parraga
- Trial code
- NCT02351141
- Record updated
- 31 July 2026
- Original description
The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 200 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.Read full original descriptionShow less
Structure and Function MRI of Asthma
The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 200 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.
Inclusion: Subjects male and female aged 18-60 with a clinical diagnosis of asthma; Smoking history ≤ 1 pack/year; Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent; Subject is judged to be in otherwise stable health on the basis of medical history; Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.); FEV1 >60% predicted.
Exclusion: Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.) (At the discretion of the MRI Technologist/3T Manager); In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia; Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material; Patient is unable to perform spirometry or plethysmography maneuvers; Patient is pregnant.