Study of asthma and wheezing patterns in German children
Observes children with wheeze or asthma to learn what drives different disease patterns.
Plain-language title generated from the registry record
Registry title: Pediatric Arm of DZL All Age Asthma Cohort
Key facts
- Where
- Cologne, Hanover, Lübeck, Marburg, and Munich, GermanySee the 5 sites
Where in Germany
- University Children's Hospital Cologne, Department of Paediatric Allergology and PneumologyCologne, GermanyTaking people
- Medizinische Hochschule Hannover, Biomedical Research in Endstage and Obstructive Lung DiseaseHanover, GermanyTaking people
- Universitaetsklinikum Schleswig-Holstein, Klinik für Kinder- und Jugendmedizin, Airway Research Center NorthLübeck, GermanyTaking people
- Klinik für Kinder- und Jugendmedizin, Universitaetsklinikum Giessen und Marburg GmbH, Universities of Giessen and Marburg Lung CenterMarburg, GermanyTaking people
- Klinikum der Universitaet Muenchen, Comprehensive Pulmonary Center MunichMunich, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- LMU Klinikum
- Trial code
- NCT02496468
- Record updated
- 28 August 2024
- Original description
Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).Read full original descriptionShow less
The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Pediatric Arm
Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).
Inclusion: informed consent by parents (and by children if age > 8 years); age 6 months to 18 years; term delivery (≥ 37 weeks); active/passive understanding of German; age 6 months - < 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion); age at least 6 years: doctor diagnosed asthma (according to current guidelines).
Exclusion: oxygen therapy after birth with a duration of more than 24 hours; fever of at least 38.5°C during the last two weeks prior to the planned first visit; known inborn or perinatal pulmonary disease; heart failure diagnosed after birth affecting pulmonary circulation; major respiratory diseases such as e.g. interstitial lung disease; airway malformation; ventilator support or mechanical ventilation after birth; diagnoses of cystic fibrosis; primary ciliary dyskinesia; any current non-atopic comorbidity.