Tests brain stimulation patterns for movement symptoms in several conditions
Tests timing patterns of deep brain stimulation in people with Parkinson's, tremor, dystonia or MS.
Plain-language title generated from the registry record
Registry title: Effects of Stimulation Patterns of Deep Brain Stimulation
Key facts
- Where
- Atlanta, Durham, and Gainesville, United StatesSee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 21 and 80 years old?
Source: NCT02553525, who can take part
Where in United States
- Emory UniversityAtlanta, United StatesNo longer taking part
- Duke UniversityDurham, United StatesNo longer taking part
- University of FloridaGainesville, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Duke University
- Trial code
- NCT02553525
- Record updated
- 9 April 2026
- Original description
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.Read full original descriptionShow less
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.
Inclusion: Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS); Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery; Neurologically stable; Able to understand the study and consent form.
Exclusion: Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications; Inability to execute the motor tasks during the study; Clinically ineffective DBS.