Growing head and neck tumor samples in mice to test new targeted treatments
Collects tumor tissue from adults with head and neck cancer to grow in mice.
Key facts
- Who runs it
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Where
- Brussels, BelgiumSee the site
- Trial code
- Registry title
- Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer
- Status
- Recruiting
- People taking part
- 40 people, planned
- Started
- Sept 2015
- Planned end
- Dec 2025
- Type of study
- Observational
- Treatments tested
- Local biopsy in the tumor
- Record updated
- 3 December 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with head and neck cancer, newly diagnosed or returned, who agree to give tumor tissue for lab models of the cancer.
- Age
- 18 years or older
- Sex
- Men and women can join
- Disease stage
- Head and neck cancer, either first diagnosis or recurrent or metastatic disease
- Earlier treatment
- Not specified
Main reasons for not taking part
- Data on stage, grade, histology, adjuvant treatment, responses and relapse must be available
- Follow-up data must be available
- Written informed consent must be given
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- In the first phase, all patients with primary or recurrent/ metastatic disease of head and neck cancer can be included pre-operatively or before a tumor biopsy after obtaining informed consent
- Data on stage, grade, histology, adjuvant treatment, responses, relapse should be available
- Follow-up data should be available
- Patients with recurrent disease are allowed
- Written informed consent
Where in Belgium
- Cliniques universitaires Saint-LucBrussels, BelgiumContact: Jean-Pascal Machiels, MD, PhDTaking people
About the trial
What the trial wants to find out
The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to:
Read full original descriptionShow less
generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer
* perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors * evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options * evaluate biomarkers of drug sensitivity * study primary and secondary (acquired) resistance in these models
Treatments tested
- Local biopsy in the tumor
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Establishment of Primary Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer for Preclinical Evaluation of Targeted Therapies.
- Plain-language title
- Growing head and neck tumor samples in mice to test new targeted treatmentsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 3 December 2024