Collecting Tissue and Samples from Men with Prostate Cancer
Studies blood, tissue and fluid samples from men with prostate cancer.
Plain-language title generated from the registry record
Registry title: Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue
Key facts
- Where
- Bethesda, United StatesSee the site
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT02594202
- Record updated
- 9 November 2026
- Original description
Background:Read full original descriptionShow less
Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue
Background:
Prostate cancer is the most common noncutaneous cancer among men in the U.S. Researchers want to study blood, tissue, and fluid samples of people with prostate cancer. This will help them understand any changes in cells and genes. These changes might lead to the development and progression of prostate cancer. Researchers think the study could lead to new treatments.
Objective:
To understand the changes in cells and genes that lead to the development and progression of prostate cancer. This could lead to new treatments.
Eligibility:
Men ages 18 and older who have or are suspected to have prostate cancer
Design:
Participants will be screened with physical exam and medical history.
Participants will send tissue blocks of their tumor, if possible. If not, they will provide unstained slides of tumor tissue.
Participants may provide samples of blood, urine, saliva, and prostate secretions.
Participants may have imaging tests. They will lie in a machine that takes pictures of their body. These tests include:
MRI of the prostate
CT of the abdomen and pelvis
Chest x-ray
Participants may need a biopsy or surgery for treatment of their cancer. If so, researchers will collect tissue.
Participants may answer questions about their prostate cancer and quality of life.
Participants may have follow-up visits or other treatments. They may have follow-up phone calls every few months.
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Exclusion: Subjects whose comorbidities would preclude diagnostic or therapeutic intervention.
INCLUSION CRITERIA:; Adults (greater than or equal to 18 years of age) with biopsy-proven or suspected prostate cancer (elevated PSA abnormal digital rectal exam (DRE) abnormal prostate MRI, or family history) who require and are willing to undergo diagnostic or therapeutic intervention as part of their diagnosis, standard of care treatment, or follow-up/surveillance for their neoplasm; ECOG performance status of 0-2; Must be willing and able to provide informed consent; PSA > or equal to 1.0 ng/ml (for patients aged 30 - 49 years) OR; PSA > or equal to 2.5 ng/ml (for patients 50 years or older) OR; Abnormal DRE (i.e. enlarged, asymmetric, nodular, firm or tender) OR; Abnormal prostate MRI finding OR; Family history of first degree relatives (brother or father) with prostate cancer or first-degree relatives (mother or sister) with breast or ovarian cancer.