Brain scans to find who responds poorly to early psychosis care
Studies brain MRI scans in young adults with a first psychotic episode, schizophrenia.
Plain-language title generated from the registry record
Registry title: Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies
Key facts
- Where
- Bron, Clermont-Ferrand, Grenoble, Lyon, and Saint-Etienne, FranceSee the 5 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 35 years old?
Source: NCT02670447, who can take part
Where in France
- Chu Le VinatierBron, FranceNot yet recruiting
- CHU Clermont-FerrandClermont-Ferrand, FranceNot yet recruiting
- Chu GrenobleGrenoble, FranceNot yet recruiting
- Hopital Edouard HerriotLyon, FranceNot yet recruiting
- CHU Saint-EtienneSaint-Etienne, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Universitaire de Saint Etienne
- Trial code
- NCT02670447
- Record updated
- 22 September 2026
- Original description
Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.Read full original descriptionShow less
Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies: A Multicentric Study
Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.
Inclusion: men and women aged 18-35 years; member or beneficiary of a social security scheme,; for women, appropriate contraception will be mandatory, as well as a negative pregnancy test,; patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the DMS V; having never received anti-psychotic treatment,; followed in the hospital or outpatient,; having given their written informed consent,; that the physical examination revealed no significant clinical abnormalities.
Exclusion: Female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical); Participating in another clinical trial or being in an exclusion period of the previous protocol; Presenting a serious somatic or neurological disease, especially Parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney; Featuring against-indication for an MRI; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3T MRI; Having a history of alcohol or drug abuse in the past year; Patients pregnant or nursing; Patients likely to exhibit aggressive behavior self according to the judgment of the investigators.