Short Course Radiation Before Surgery for Soft Tissue Sarcoma
Tests 5-day radiation therapy before surgery in adults with soft tissue sarcoma.
Plain-language title generated from the registry record
Registry title: Phase II Study of 5-Day Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcomas: Expansion Cohort
Key facts
- Where
- Los Angeles, United StatesSee the site
Where in United States
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jonsson Comprehensive Cancer Center
- Trial code
- NCT02701153
- Record updated
- 10 March 2026
- Original description
This phase II trial studies the side effects of hypofractionated radiation therapy in treating patients with soft tissue sarcomas prior to surgery. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects.Read full original descriptionShow less
Phase II Study of 5-Day Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcomas: Expansion Cohort
This phase II trial studies the side effects of hypofractionated radiation therapy in treating patients with soft tissue sarcomas prior to surgery. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects.
Inclusion: Histologically confirmed soft tissue sarcoma of the extremity/trunk; Intermediate or high grade sarcoma; Resectable primary lesion (patients with pre-existing metastasis will be included if their primary is still going to be resected); Recurrent, any grade, no previous radiation therapy; Karnofsky performance status (KPS) >= 70 or Eastern Cooperative Oncology Group (ECOG) 0 - 2; If a woman is of childbearing potential, a negative serum pregnancy test must be documented.
Exclusion: History of prior irradiation to the area to be treated; Pre-operative chemotherapy (post-op acceptable); Active treatment of a separate malignancy.