Studies tumor samples from children and teens with melanocytic skin lesions
Analyzes molecular features of melanoma and related skin lesions in young patients.
Key facts
- Who runs it
- St. Jude Children's Research Hospital
- Where
- Memphis, United StatesSee the site
- Trial code
- Registry title
- Molecular Analysis of Childhood and Adolescent Melanocytic Lesions
- Status
- Recruiting
- People taking part
- 500 people, planned
- Started
- 31 May 2016
- Expected to end
- 31 May 2041
- Type of study
- Observational
- Record updated
- 10 November 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and teenagers who were diagnosed with a suspected or confirmed melanocytic skin lesion, such as melanoma, and who have tissue available for lab studies.
- Age
- Under 19 years old at the time of diagnosis (maximum age 18 years).
- Sex
- All sexes can join.
- Disease stage
- A suspected or confirmed melanocytic lesion: adult-type melanoma, spitzoid melanoma or atypical Spitz tumor, congenital melanoma, melanoma in a giant congenital nevus, or a lesion with indeterminate biological behavior.
- Biomarker or test result
- Tissue must be available for biologic studies.
Main reasons for not taking part
- Ocular melanoma
- Cannot or will not give consent (participant or legal guardian)
- A tissue diagnosis other than the melanocytic lesions listed
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:; Conventional or "adult-type" melanoma; Spitzoid melanoma/atypical Spitz tumor; Congenital melanoma; Melanoma arising in a giant congenital nevus; Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
- Participant was <19 years of age at the time of diagnosis
- Tissue is available for biologic studies
- Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials
Who cannot take part
- Ocular melanoma
- Inability or unwillingness of research participant or legal guardian to consent
- Histologic diagnosis other than melanocytic lesion described in 3.1.1
Where in United States
- St. Jude Children's Research HospitalMemphis, United StatesContact: Alberto Pappo, MDTaking people
About the trial
What the trial wants to find out
This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions.
Read full original descriptionShow less
PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi).
SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Molecular Analysis of Childhood and Adolescent Melanocytic Lesions
- Plain-language title
- Studies tumor samples from children and teens with melanocytic skin lesionsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 10 November 2025