Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Reason given: lack of patient
Key facts
- Where
- Caen, FranceSee the site
Where in France
- CHU de CAENCaen, FranceNo longer taking part
Trial details
- Who runs it
- University Hospital, Caen
- Trial code
- NCT02789098
- Record updated
- 18 June 2026
- Original description
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.Read full original descriptionShow less
Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.
Inclusion: First ST Elevation Myocardial Infarction; Primary Percutaneous Coronary Intervention (TIMI 3); Single vessel coronary artery disease; Age over 18 years; Informed Consent dated and signed; Written and spoken French; Beneficiary of social security insurance.
Exclusion: Significant two or three-vessel coronary artery disease (> 70% stenosis in at least one of the other two coronary arteries); Past history of myocardial infarction before STEMI; Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure; Age under 18 years or guardianship; No Primary Percutaneous Coronary Intervention; TIMI 0-2 after Primary Percutaneous Coronary Intervention; Pregnant and / or lactating.