Tests a tumor signature in adults with soft-tissue sarcoma before chemotherapy
Studies a tumor biomarker in adults with non-metastatic soft-tissue sarcoma receiving chemotherapy.
Plain-language title generated from the registry record
Registry title: CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.
Key facts
- Where
- Bordeaux, Dijon, Lille, Lyon, Marseille, Nantes, Paris, Toulouse, and Villejuif, FranceSee the 10 sites
Where in France
- Institut BergonieBordeaux, FranceTaking people
- Centre Georges François LeclercDijon, FranceTaking people
- Centre Oscar LambretLille, FranceNot yet recruiting
- Centre Leon BerardLyon, FranceTaking people
- AP-HM - Hopital de la TimoneMarseille, FranceTaking people
- Institut Paoli-CalmettesMarseille, FranceTaking people
- Institut de Cancérologie de l'OuestNantes, FranceTaking people
- Institut CurieParis, FranceNot yet recruiting
- Institut Claudius Regaud - IUCT-0Toulouse, FranceTaking people
- Institut Gustave RoussyVillejuif, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institut Bergonié
- Trial code
- NCT02789384
- Record updated
- 8 October 2026
- Original description
This is a prospective observational biomarker study including patients with non-metastatic, soft-tissue sarcomas (STS) for whom neoadjuvant chemotherapy is considered as the best option by the multidisciplinary sarcoma team of one of the participating centers.Read full original descriptionShow less
Prognostic Value of the CINSARC (Complexity Index in Sarcoma) Signature and Correlation With Chemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study. (NEOSarcomics )
This is a prospective observational biomarker study including patients with non-metastatic, soft-tissue sarcomas (STS) for whom neoadjuvant chemotherapy is considered as the best option by the multidisciplinary sarcoma team of one of the participating centers.
Inclusion: Histologically confirmed soft-tissue sarcoma by central review, except if the diagnosis was already confirmed by the RRePS (Réseau de Référence en Pathologie des Sarcomes et des Viscères) Network,; Available archived frozen tumor tissue sample or patient consenting to undergo a biopsy of the tumour for research purpose,; Non-metastatic disease, for which the use of chemotherapy to "downstage" the sarcoma prior to surgery, is assumed to result in better local tumor control by the multidisciplinary sarcoma team of one of the French reference centers involved in this study,; Age ≥ 18 years,; Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤ 1,; Measurable disease according to RECIST v1.1 outside any previously irradiated field,; Neoadjuvant anthracycline-based chemotherapy proposed as the best option by the multidisciplinary sarcoma team of one of the French reference centers involved in this study,; No prior or concurrent malignant disease diagnosed or treated in the last 2 years except for adequately treated in situ carcinoma of the cervix, basal or squamous skin cell carcinoma, or in situ transitional bladder cell carcinoma,; Voluntarily signed and dated written informed consents prior to any study specific procedure,; Patients with a social security in compliance with the French Law relating to biomedical research (Article 1121-11 of French Public Health Code).
Exclusion: Previous treatment for the sarcoma,; Contra-indication precluding the administration of chemotherapy as assessed by the investigator,; Previous enrolment in the present study,; Pathological diagnosis different from a soft-tissue sarcoma,; Histological subtypes: well-differentiated liposarcoma, alveolar soft-part sarcoma, dermatofibrosarcoma protuberans, clear-cell sarcoma, rhabdomyosarcoma,; Participation to a study involving a medical or therapeutic intervention in the last 30 days,; Pregnant or breast feeding women,; Patient unable to follow and comply with the study procedures because of any geographical, social or psychological reasons.