Tests less radiotherapy for children with Hodgkin lymphoma
Tests chemotherapy with or without radiotherapy in children with Hodgkin lymphoma.
Plain-language title generated from the registry record
Registry title: Treatment for Classical Hodgkin Lymphoma in Children and Adolescents
Key facts
- Where
- Petah Tikva, IsraelSee the site
Where in Israel
- Schneider Children's Medical CenterPetah Tikva, IsraelTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- GALIA AVRAHAMI
- Trial code
- NCT02797717
- Record updated
- 14 June 2016
- Original description
Reduction of the indication for radiotherapy (RT) in newly diagnosed patients with classical Hodgkins lymphoma without compromising cure rates. Investigation of a chemotherapy intensification randomisation in intermediate and advanced classical Hodgkins lymphoma patients to compensate for reduction in RT.Read full original descriptionShow less
An International, Multicentre, Randomised Controlled Trial. Treatment for Classical Hodgkin Lymphoma in Children and Adolescents Standard Treatment (Chemotherapy and RT) Compared With Experimental Treatment (Chemotherapy Without RT or Restricted to RT)
Reduction of the indication for radiotherapy (RT) in newly diagnosed patients with classical Hodgkins lymphoma without compromising cure rates. Investigation of a chemotherapy intensification randomisation in intermediate and advanced classical Hodgkins lymphoma patients to compensate for reduction in RT.
Inclusion: histologically confirmed primary diagnosis of classical Hodgkin's lymphoma; patients under 18 years of age on the date of written informed consent. In specialized Teenage and Young Adult (TYA) units in Australia, France, Italy, New Zealand and United Kingdom patients up to under 25 years of age can also be enrolled. Lower age limits will be country specific according to national laws or formal insurance requirements that may preclude very young patients; written informed consent of the patient and/or the patient's parents or guardian according to national laws; negative pregnancy test within 2 weeks prior to starting treatment for female patients with childbearing potential.
Exclusion: prior chemotherapy or radiotherapy for other malignancies; pre-treatment of Hodgkin's lymphoma (except for steroid pre-phase to a maximum of 7-10 days for emergency treatment of a large mediastinal tumour); severe concomitant diseases (e.g. immune deficiency syndrome); patients who are sexually active and are unwilling to use adequate contraception during therapy and for one month after last trial treatment; current or recent (within 30 days prior to date of written informed consent) treatment with another investigational drug or participation in another interventional clinical trial; other (simultaneous) malignancies; contraindication or known hypersensitivity to study drugs; known HIV-positivity; diagnosis of lymphocyte-predominant Hodgkin's lymphoma; residence outside the participating countries where long term follow-up cannot be guaranteed; pregnancy and / or lactation.