Studying Small Blood Vessel Function in People With Cardiac Amyloidosis
Observes small heart blood vessel function in adults with cardiac amyloidosis, a heart disease.
Plain-language title generated from the registry record
Registry title: Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
Key facts
- Where
- Seoul, South KoreaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT02798705, who can take part
Where in South Korea
- Samsung Medical CenterSeoul, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Samsung Medical Center
- Trial code
- NCT02798705
- Record updated
- 14 March 2025
- Original description
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test including serum light chain amount, Doppler echocardiography with 2D strain, and cardiac perfusion MRI. The third object of this study is to evaluate the association between physiologic indices and pathologically measured percent area involvement of interstitium.Read full original descriptionShow less
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis: Prospective Registry and Pilot Study
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test including serum light chain amount, Doppler echocardiography with 2D strain, and cardiac perfusion MRI. The third object of this study is to evaluate the association between physiologic indices and pathologically measured percent area involvement of interstitium.
Inclusion: Subject age 18-85 years old; Patients with confirmed cardiac amyloidosis by heart biopsy; Patients with confirmed amyloidosis by biopsy other than heart and evidence of cardiac involvement in echocardiography; Patients who underwent invasive physiologic assessment within 3 months from diagnosis of primary disease.
Exclusion: Patients with major bleeding in last 3 months; Patients with active bleeding; Patients with severe valvular heart disease; Patients with cardiogenic shock; Patients with unstable vital sign that precludes coronary angiography; Patients with coagulopathy; Patients who refused to provide informed consent.