Compares two dialysis salt levels in people with kidney failure
Tests two dialysis sodium levels in adults receiving maintenance haemodialysis for kidney failure.
Plain-language title generated from the registry record
Registry title: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Key facts
- Where
- Ampang, Batu Pahat, Beaufort, George Town, Ipoh, Johor Bahru, Kajang, Kangar, Klang, Kota Bharu, Kota Kinabalu, Kuala Kangsar, Kuala Lipis, Kuala Lumpur, Kuantan, Kudat, Kulim, Labuan, Langgar, Lenggong, Malacca, Muar town, Permatang Pauh, Petaling Jaya, Shah Alam, Sungai Petani, Sungai Siput, Tambunan, and Temerluh, MalaysiaSee the 39 sites
- Phase
- Phase 4
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for dialysis units that treat adults on long-term haemodialysis. Each unit is randomly given one of two default dialysate sodium levels.
- Age
- 18 years or older (patients treated at the site).
- Sex
- All sexes.
- Disease stage
- Adults receiving maintenance haemodialysis (end-stage kidney disease).
- Earlier treatment
- The unit must use a default dialysate sodium concentration for most sessions. Fewer than 15% of patients withdrew for social reasons in the first two years of dialysis.
Main reasons for not taking part
- Unit with fewer than 10 dialysis recipients at the time of randomisation
- Unit that is not self-contained
- Home dialysis training or support unit
- Unit not willing to accept randomisation to either option
- Unit not able to comply with data collection methods
This trial only enrols participants on dialysis. The registry sentence this rests on: Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis
Read by machine on 12 November 2026.
Where in Malaysia
- Hospital AmpangAmpang, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultanah Nora IsmailBatu Pahat, MalaysiaContact: Grace BalickiTaking people
- Hospital BeaufortBeaufort, MalaysiaContact: Grace BalickiTaking people
- Hospital Pulau PinangGeorge Town, MalaysiaContact: Grace BalickiTaking people
- Pusat Dialisis NKF- Yayasan Dialisis Pendidikan Akhlak PerakIpoh, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultan IsmailJohor Bahru, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultanah AminahJohor Bahru, MalaysiaContact: Grace BalickiTaking people
- Hospital KajangKajang, MalaysiaContact: Grace BalickiTaking people
- Hospital SerdangKajang, MalaysiaContact: Grace BalickiTaking people
- Pusat Rawatan Dialisis Tuanku Syed Putra - NKFKangar, MalaysiaContact: Grace BalickiTaking people
- Hospital Tuanku FauziahKangar, MalaysiaContact: Grace BalickiNo longer taking part
- Hospital Tengku Ampuan RahimahKlang, MalaysiaContact: Grace BalickiTaking people
- Pusat Daillisis NKF - Kelab ApexKlang, MalaysiaContact: Grace BalickiTaking people
- Hospital Raja Perempuan Zainab IIKota Bharu, MalaysiaContact: Grace BalickiTaking people
- Hospital LikasKota Kinabalu, MalaysiaContact: Grace BalickiTaking people
- Hospital Queen Elizabeth IIKota Kinabalu, MalaysiaContact: Grace BalickiTaking people
- Hospital Kuala KangsarKuala Kangsar, MalaysiaContact: Grace BalickiTaking people
- Hospital Kuala LipisKuala Lipis, MalaysiaContact: Grace BalickiTaking people
- Hospital Kuala LumpurKuala Lumpur, MalaysiaContact: Grace BalickiTaking people
- Pusat Dialisis NKF-Fungates SuperflowKuala Lumpur, MalaysiaContact: Grace BalickiTaking people
- Pusat Dialisis NKF-NanyangKuala Lumpur, MalaysiaContact: Grace BalickiTaking people
- Universiti Kebangsaan Malaysia Medical CentreKuala Lumpur, MalaysiaContact: Grace BalickiTaking people
- University of Malaya Medical CentreKuala Lumpur, MalaysiaContact: Grace BalickiTaking people
- Hospital Tengku Ampuan AfzanKuantan, MalaysiaContact: Grace BalickiTaking people
- Hospital KudatKudat, MalaysiaContact: Grace BalickiTaking people
- Hospital KulimKulim, MalaysiaContact: Grace BalickiTaking people
- Hospital LabuanLabuan, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultanah BahiyahLanggar, MalaysiaContact: Grace BalickiTaking people
- Haemodialysis Unit Klinik Kesihatan LenggongLenggong, MalaysiaContact: Grace BalickiTaking people
- Pusat Hemodialisis Komuniti ChengMalacca, MalaysiaContact: Grace BalickiTaking people
- Hospital Pakar Sultanah FatimahMuar town, MalaysiaContact: Grace BalickiTaking people
- Hospital Seberang JayaPermatang Pauh, MalaysiaContact: Grace BalickiTaking people
- Pusat Dialisis NKF - ChempakaPetaling Jaya, MalaysiaContact: Grace BalickiTaking people
- Hospital Shah AlamShah Alam, MalaysiaContact: Grace BalickiTaking people
- Universiti Teknologi MaraShah Alam, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultan Abdul HalimSungai Petani, MalaysiaContact: Grace BalickiTaking people
- Hospital Sungai SiputSungai Siput, MalaysiaContact: Grace BalickiTaking people
- Hospital TambunanTambunan, MalaysiaContact: Grace BalickiTaking people
- Hospital Sultan Haji Ahmad ShahTemerluh, MalaysiaContact: Grace BalickiTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Sydney
- Trial code
- NCT02823821
- Record updated
- 4 April 2025
- Original description
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.Read full original descriptionShow less
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
The site inclusion criteria are:; Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis; Rates of withdrawal within the first two years of commencing dialysis for social reasons have been less than 15% for the 2 years prior to recruitment and are not expected to increase above 15%; Has a minimum of 10 dialysis recipients at time of randomisation; Utilises a default dialysate sodium concentration at the time of recruitment (a substantial majority of dialysis sessions are conducted with the default dialysate sodium concentration); Is a self-contained unit (i.e. unit patients do not regularly rotate through another unit. Brief trips by patients to a parent or other unit do not exclude a site); Willing to accept randomisation to either intervention (as determined by nominated Director of Unit); Is not a home dialysis training or support unit. [Sites that include both in-center/satellite dialysis patients and home patients may participate but the study procedures and assessments will only be conducted in the incenter/satellite component of the site]; The exclusion criteria are:; Not able to comply with data collection methods.