Compares two dialysis salt levels in people with kidney failure
Tests two dialysis sodium levels in adults receiving maintenance haemodialysis for kidney failure.
Plain-language title generated from the registry record
Registry title: Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
Key facts
- Where
- Ampang, Batu Pahat, Beaufort, George Town, Ipoh, Johor Bahru, Kajang, Kangar, Klang, Kota Bharu, Kota Kinabalu, Kuala Kangsar, Kuala Lipis, Kuala Lumpur, Kuantan, Kudat, Kulim, Labuan, Langgar, Lenggong, Malacca, Muar town, Permatang Pauh, Petaling Jaya, Shah Alam, Sungai Petani, Sungai Siput, Tambunan, and Temerluh, MalaysiaSee the 39 sites
- Phase
- Phase 4
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for dialysis units that treat adults on long-term haemodialysis. Each unit is randomly given one of two default dialysate sodium levels.
- Age
- 18 years or older (patients treated at the site).
- Sex
- All sexes.
- Disease stage
- Adults receiving maintenance haemodialysis (end-stage kidney disease).
- Earlier treatment
- The unit must use a default dialysate sodium concentration for most sessions. Fewer than 15% of patients withdrew for social reasons in the first two years of dialysis.
Main reasons for not taking part
- Unit with fewer than 10 dialysis recipients at the time of randomisation
- Unit that is not self-contained
- Home dialysis training or support unit
- Unit not willing to accept randomisation to either option
- Unit not able to comply with data collection methods
This trial only enrols participants on dialysis. The registry sentence this rests on: Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis
Read by machine on 9 November 2026.
Where in Malaysia
- Hospital AmpangAmpang, MalaysiaTaking people
- Hospital Sultanah Nora IsmailBatu Pahat, MalaysiaTaking people
- Hospital BeaufortBeaufort, MalaysiaTaking people
- Hospital Pulau PinangGeorge Town, MalaysiaTaking people
- Pusat Dialisis NKF- Yayasan Dialisis Pendidikan Akhlak PerakIpoh, MalaysiaTaking people
- Hospital Sultan IsmailJohor Bahru, MalaysiaTaking people
- Hospital Sultanah AminahJohor Bahru, MalaysiaTaking people
- Hospital KajangKajang, MalaysiaTaking people
- Hospital SerdangKajang, MalaysiaTaking people
- Pusat Rawatan Dialisis Tuanku Syed Putra - NKFKangar, MalaysiaTaking people
- Hospital Tuanku FauziahKangar, MalaysiaNo longer taking part
- Hospital Tengku Ampuan RahimahKlang, MalaysiaTaking people
- Pusat Daillisis NKF - Kelab ApexKlang, MalaysiaTaking people
- Hospital Raja Perempuan Zainab IIKota Bharu, MalaysiaTaking people
- Hospital LikasKota Kinabalu, MalaysiaTaking people
- Hospital Queen Elizabeth IIKota Kinabalu, MalaysiaTaking people
- Hospital Kuala KangsarKuala Kangsar, MalaysiaTaking people
- Hospital Kuala LipisKuala Lipis, MalaysiaTaking people
- Hospital Kuala LumpurKuala Lumpur, MalaysiaTaking people
- Pusat Dialisis NKF-Fungates SuperflowKuala Lumpur, MalaysiaTaking people
- Pusat Dialisis NKF-NanyangKuala Lumpur, MalaysiaTaking people
- Universiti Kebangsaan Malaysia Medical CentreKuala Lumpur, MalaysiaTaking people
- University of Malaya Medical CentreKuala Lumpur, MalaysiaTaking people
- Hospital Tengku Ampuan AfzanKuantan, MalaysiaTaking people
- Hospital KudatKudat, MalaysiaTaking people
- Hospital KulimKulim, MalaysiaTaking people
- Hospital LabuanLabuan, MalaysiaTaking people
- Hospital Sultanah BahiyahLanggar, MalaysiaTaking people
- Haemodialysis Unit Klinik Kesihatan LenggongLenggong, MalaysiaTaking people
- Pusat Hemodialisis Komuniti ChengMalacca, MalaysiaTaking people
- Hospital Pakar Sultanah FatimahMuar town, MalaysiaTaking people
- Hospital Seberang JayaPermatang Pauh, MalaysiaTaking people
- Pusat Dialisis NKF - ChempakaPetaling Jaya, MalaysiaTaking people
- Hospital Shah AlamShah Alam, MalaysiaTaking people
- Universiti Teknologi MaraShah Alam, MalaysiaTaking people
- Hospital Sultan Abdul HalimSungai Petani, MalaysiaTaking people
- Hospital Sungai SiputSungai Siput, MalaysiaTaking people
- Hospital TambunanTambunan, MalaysiaTaking people
- Hospital Sultan Haji Ahmad ShahTemerluh, MalaysiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sydney
- Trial code
- NCT02823821
- Record updated
- 4 April 2025
- Original description
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.Read full original descriptionShow less
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients receiving maintenance haemodialysis.
The site inclusion criteria are:; Predominantly dialyses adults (≥18 years old) receiving maintenance haemodialysis; Rates of withdrawal within the first two years of commencing dialysis for social reasons have been less than 15% for the 2 years prior to recruitment and are not expected to increase above 15%; Has a minimum of 10 dialysis recipients at time of randomisation; Utilises a default dialysate sodium concentration at the time of recruitment (a substantial majority of dialysis sessions are conducted with the default dialysate sodium concentration); Is a self-contained unit (i.e. unit patients do not regularly rotate through another unit. Brief trips by patients to a parent or other unit do not exclude a site); Willing to accept randomisation to either intervention (as determined by nominated Director of Unit); Is not a home dialysis training or support unit. [Sites that include both in-center/satellite dialysis patients and home patients may participate but the study procedures and assessments will only be conducted in the incenter/satellite component of the site]; The exclusion criteria are:; Not able to comply with data collection methods.