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Taking people in South KoreaPhase 4

Tests defibrillator implants added to medicine for variant angina patients

Tests a heart defibrillator plus medicine versus medicine alone in adults with variant angina.

Plain-language title generated from the registry record
Registry title: Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death

Key facts

Where
Bucheon-si, Busan, Cheonan, Daegu, Daejeon, Gangneung, Gwangju, Iksan, Ilsan, Incheon, Jeonju, Sejong, Seongnam, Seoul, and Suwon, South KoreaSee the 26 sites
Phase
Phase 4

Where in South Korea

  • Soon Chun Hyang University Hospital BucheonBucheon-si, South KoreaTaking people
  • Busan National University Yangsan HospitalBusan, South KoreaTaking people
  • Dong-A Medical CenterBusan, South KoreaTaking people
  • Busan University HospitalBusan, South KoreaNo longer taking part
  • Soon Chun Hyang University Hospital CheonanCheonan, South KoreaNo longer taking part
  • Keimyung University - Dongsan Medical CenterDaegu, South KoreaTaking people
  • Chungnam National University HospitalDaejeon, South KoreaTaking people
  • Gangneung Asan HospitalGangneung, South KoreaNo longer taking part
  • Chonnam National University HospitalGwangju, South KoreaTaking people
  • Wonkwang University HospitalIksan, South KoreaNo longer taking part
  • Inje University Ilsan Paik HospitalIlsan, South KoreaTaking people
  • Gachon University Gil Medical CenterIncheon, South KoreaTaking people
  • Chonbuk National University HospitalJeonju, South KoreaTaking people
  • Chungnam National University Sejong HospitalSejong, South KoreaTaking people
  • Seoul university Bundang hospitalSeongnam, South KoreaTaking people
  • Asan Medical CenterSeoul, South KoreaTaking people
  • Ewha Womans University Mokdong HospitalSeoul, South KoreaTaking people
  • Kangdong KyungHee University hospitalSeoul, South KoreaTaking people
  • Korea University Anam HospitalSeoul, South KoreaTaking people
  • Seoul National University Boramae Medical CenterSeoul, South KoreaTaking people
  • Seoul National University HospitalSeoul, South KoreaTaking people
  • Korea University Guro HospitalSeoul, South KoreaNo longer taking part
  • Severance hospitalSeoul, South KoreaNo longer taking part
  • The Catholic Univ. of Korea Seoul St. Mary's HospitalSeoul, South KoreaNo longer taking part
  • The Catholic University of Korea, Eunpyeong St. Mary's HospitalSeoul, South KoreaNo longer taking part
  • Ajou University HospitalSuwon, South KoreaTaking people

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Trial details

Who runs it
Kee-joon Choi
Trial code
NCT02845531
Record updated
25 June 2026
Original description
The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces the incidence of the death from any cause compared with optimal medical therapy alone.Read full original descriptionShow less

The purpose of this study is to determine whether ICD(Implantable Cardioverter Defibrillator) implantation on the top of optimal medical therapy in patients with variant angina manifesting as aborted sudden cardiac death reduces the incidence of the death from any cause compared with optimal medical therapy alone.

Inclusion: Age 18 years or older; Patients experienced successfully resuscitated cardiac arrest due to documented ventricular fibrillation or sustained rapid ventricular tachycardia; Diagnosed as variant angina, defined by spontaneous coronary spasm with ST elevation (≥0.1mV) in the coronary angiogram and/or documented coronary spasm on ergonovine provocation coronary angiography.

Exclusion: prior history of atrial or ventricular arrhythmia requiring class I or III antiarrhythmic drugs (flecainide, propafenone, amiodarone, sotalol and dronedarone); Prior catheter ablation for ventricular arrhythmia; Prior pacemaker or Implantable Cardioverter Defibrillator; Chronic Heart Failure New York Heart Association functional class III or IV; Psychiatric illnesses that may be aggravated by device implantation or that may preclude systematic follow-up; Organic heart disease known to be associated with sudden cardiac arrest; Heart failure with reduced ejection fraction (Left Ventricular Ejection Fraction < 35%); Presence of LV akinesia or aneurysm; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular dysplasia; Primary cardiac electrical diseases (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia); Life expectancy <2 years; Significant (>50%) coronary artery stenosis on coronary angiography; 2nd or 3rd degree AV block not related to coronary ischemia, requiring permanent pacemaker; Patients with poor neurologic outcome (defined as cerebral performance category scale ≥3).

ClinicalTrials.gov NCT02845531