NCT02855476Recruiting
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2500 (estimated)
- First submitted
- 26 Jul 2016
- Start date
- 1 Jan 2017
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- University College, London
- Diseases
- Huntington's disease
- NCT number
- NCT02855476
What you commit to
- Study type: Observational
- Planned participants: 2500
- From 1 Jan 2017 to the primary completion date, 30 Apr 2027
- 40 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Drug trial within 30 days of any sampling visit
- Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days)
- Antiplatelet or anticoagulant therapy within 14 days
- Needle phobia, headache, spinal surgery / deformity
- Drug / alcohol abuse
- Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days
Other illness
- Clotting or bruising disorder
Other
- Significant comorbidity
- Screening blood test abnormalities \>10% outside normal range
- Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential
- Predictable non compliance or unwillingness
Who the study is looking for
- Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD)
- Enroll HD participant
- Capable of consenting or have a legal representative (parent/guardian for juveniles)
- Capable of complying with study procedures
- All participants other than family and community controls must have had a genetic test for HD
Age in the registry: 11 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (40)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Ottawa Hospital Coordinator of this site? Confirm its status | Ottawa | Canada | Recruiting |
| North York General Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Centre for Movement Disorders Coordinator of this site? Confirm its status | Toronto | Canada | Completed |
| University of British Columbia, The Centre for Huntingtons Disease Coordinator of this site? Confirm its status | Vancouver | Canada | Active, not recruiting |
| St Josef And Elisabeth Hospital Coordinator of this site? Confirm its status | Bochum | Germany | Recruiting |
| Dresden University Coordinator of this site? Confirm its status | Dresden | Germany | Recruiting |
| University Hospital of Erlangen Coordinator of this site? Confirm its status | Erlangen | Germany | Recruiting |
| George Huntington Institute Coordinator of this site? Confirm its status | Münster | Germany | Recruiting |
| kbo-Isar-Amper-Klinikum Taufkirchen (Vils) Coordinator of this site? Confirm its status | Taufkirchen | Germany | Recruiting |
| University Hospital Ulm Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
| Hospital de Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Cruces University Hospital Coordinator of this site? Confirm its status | Bilbao | Spain | Active, not recruiting |
| Ramón y Cajal Universitary Hospital Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Centre Hospitalier Universitaire D'Angers Coordinator of this site? Confirm its status | Angers | France | Recruiting |
| Le Centre Hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Recruiting |
| Birmingham Huntingtons Disease Clinic Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| North Bristol NHS Trust Coordinator of this site? Confirm its status | Bristol | United Kingdom | Active, not recruiting |
| Cambridge University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Recruiting |
| Cardiff University Coordinator of this site? Confirm its status | Cardiff | United Kingdom | Recruiting |
| Royal Devon & Exeter NHS Foundation Trust Coordinator of this site? Confirm its status | Exeter | United Kingdom | Recruiting |
| Glasgow Clinical Research Facility Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
| Fife Health Board - Whyteman's Brae Hospital Coordinator of this site? Confirm its status | Kirkcaldy | United Kingdom | Active, not recruiting |
| Leeds Teaching Hospital Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| The Walton Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| University College London Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| St. George's, University of London Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Oxford University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Recruiting |
| University Hospitals Plymouth NHS Trust Coordinator of this site? Confirm its status | Plymouth | United Kingdom | Recruiting |
| Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Lega Italiana Ricera Huntington Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| NZ Brain Research Institute Coordinator of this site? Confirm its status | Christchurch | New Zealand | Recruiting |
| The University of Auckland Coordinator of this site? Confirm its status | Grafton | New Zealand | Recruiting |
| Institute of Psychiatry and Neurology Coordinator of this site? Confirm its status | Warsaw | Poland | Active, not recruiting |
| Gulbenkian Institute of Molecular Medicine Coordinator of this site? Confirm its status | Lisbon | Portugal | Recruiting |
| John Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| CenExel Coordinator of this site? Confirm its status | Englewood | United States | Recruiting |
| University of Texas Health Science Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Georgetown University Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| Wake Forest University Coordinator of this site? Confirm its status | Winston-Salem | United States | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.