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NCT02855476Recruiting

HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

Source: ClinicalTrials.gov · Last updated 27 Apr 2026

Brief summary (registry, in English)

HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.

Status (registry)
Recruiting
Study type
Observational
Enrollment
2500 (estimated)
First submitted
26 Jul 2016
Start date
1 Jan 2017
Primary completion date
30 Apr 2027
Lead sponsor
University College, London
NCT number
NCT02855476

What you commit to

  • Study type: Observational
  • Planned participants: 2500
  • From 1 Jan 2017 to the primary completion date, 30 Apr 2027
  • 40 sites in 10 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Drug trial within 30 days of any sampling visit
  • Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days)
  • Antiplatelet or anticoagulant therapy within 14 days
  • Needle phobia, headache, spinal surgery / deformity
  • Drug / alcohol abuse
  • Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days

Other illness

  • Clotting or bruising disorder

Other

  • Significant comorbidity
  • Screening blood test abnormalities \>10% outside normal range
  • Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential
  • Predictable non compliance or unwillingness

Who the study is looking for

  • Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD)
  • Enroll HD participant
  • Capable of consenting or have a legal representative (parent/guardian for juveniles)
  • Capable of complying with study procedures
  • All participants other than family and community controls must have had a genetic test for HD

Age in the registry: 11 years to 75 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (40)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
The Ottawa Hospital
Coordinator of this site? Confirm its status
OttawaCanadaRecruiting
North York General Hospital
Coordinator of this site? Confirm its status
TorontoCanadaRecruiting
Centre for Movement Disorders
Coordinator of this site? Confirm its status
TorontoCanadaCompleted
University of British Columbia, The Centre for Huntingtons Disease
Coordinator of this site? Confirm its status
VancouverCanadaActive, not recruiting
St Josef And Elisabeth Hospital
Coordinator of this site? Confirm its status
BochumGermanyRecruiting
Dresden University
Coordinator of this site? Confirm its status
DresdenGermanyRecruiting
University Hospital of Erlangen
Coordinator of this site? Confirm its status
ErlangenGermanyRecruiting
George Huntington Institute
Coordinator of this site? Confirm its status
MünsterGermanyRecruiting
kbo-Isar-Amper-Klinikum Taufkirchen (Vils)
Coordinator of this site? Confirm its status
TaufkirchenGermanyRecruiting
University Hospital Ulm
Coordinator of this site? Confirm its status
UlmGermanyRecruiting
Hospital de Sant Pau
Coordinator of this site? Confirm its status
BarcelonaSpainRecruiting
Cruces University Hospital
Coordinator of this site? Confirm its status
BilbaoSpainActive, not recruiting
Ramón y Cajal Universitary Hospital
Coordinator of this site? Confirm its status
MadridSpainRecruiting
Centre Hospitalier Universitaire D'Angers
Coordinator of this site? Confirm its status
AngersFranceRecruiting
Le Centre Hospitalier Universitaire de Bordeaux
Coordinator of this site? Confirm its status
BordeauxFranceRecruiting
Birmingham Huntingtons Disease Clinic
Coordinator of this site? Confirm its status
BirminghamUnited KingdomRecruiting
North Bristol NHS Trust
Coordinator of this site? Confirm its status
BristolUnited KingdomActive, not recruiting
Cambridge University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
CambridgeUnited KingdomRecruiting
Cardiff University
Coordinator of this site? Confirm its status
CardiffUnited KingdomRecruiting
Royal Devon & Exeter NHS Foundation Trust
Coordinator of this site? Confirm its status
ExeterUnited KingdomRecruiting
Glasgow Clinical Research Facility
Coordinator of this site? Confirm its status
GlasgowUnited KingdomRecruiting
Fife Health Board - Whyteman's Brae Hospital
Coordinator of this site? Confirm its status
KirkcaldyUnited KingdomActive, not recruiting
Leeds Teaching Hospital Trust
Coordinator of this site? Confirm its status
LeedsUnited KingdomRecruiting
The Walton Centre NHS Foundation Trust
Coordinator of this site? Confirm its status
LiverpoolUnited KingdomRecruiting
University College London Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
LondonUnited KingdomRecruiting
St. George's, University of London
Coordinator of this site? Confirm its status
LondonUnited KingdomRecruiting
Oxford University Hospitals NHS Foundation Trust
Coordinator of this site? Confirm its status
OxfordUnited KingdomRecruiting
University Hospitals Plymouth NHS Trust
Coordinator of this site? Confirm its status
PlymouthUnited KingdomRecruiting
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Coordinator of this site? Confirm its status
MilanItalyActive, not recruiting
Lega Italiana Ricera Huntington
Coordinator of this site? Confirm its status
RomeItalyRecruiting
NZ Brain Research Institute
Coordinator of this site? Confirm its status
ChristchurchNew ZealandRecruiting
The University of Auckland
Coordinator of this site? Confirm its status
GraftonNew ZealandRecruiting
Institute of Psychiatry and Neurology
Coordinator of this site? Confirm its status
WarsawPolandActive, not recruiting
Gulbenkian Institute of Molecular Medicine
Coordinator of this site? Confirm its status
LisbonPortugalRecruiting
John Hopkins University
Coordinator of this site? Confirm its status
BaltimoreUnited StatesRecruiting
CenExel
Coordinator of this site? Confirm its status
EnglewoodUnited StatesRecruiting
University of Texas Health Science Center
Coordinator of this site? Confirm its status
HoustonUnited StatesRecruiting
Vanderbilt University Medical Center
Coordinator of this site? Confirm its status
NashvilleUnited StatesRecruiting
Georgetown University
Coordinator of this site? Confirm its status
Washington D.C.United StatesRecruiting
Wake Forest University
Coordinator of this site? Confirm its status
Winston-SalemUnited StatesCompleted

This page is information, not medical advice. Discuss any trial with your doctor.