NCT02867085Completed
Study Investigating the Interactions of Bone and Hematopoiesis in the Elderly
A Prospective Longitudinal Cohort Study to Investigate the Interactions of Bone and Hematopoiesis in the Elderly
Source: ClinicalTrials.gov · Last updated 24 Aug 2025
Brief summary (registry, in English)
The prospective BoHemE study is designed to evaluate the correlation between bone marrow function and skeletal health in elderly patients (\>= 60 years) with or without pre-existing myelodysplastic syndromes (MDS).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 297 (actual)
- First submitted
- 27 Jul 2016
- Start date
- 19 Jul 2017
- Primary completion date
- 1 Aug 2024
- Lead sponsor
- Technische Universität Dresden
- Diseases
- Myelodysplastic syndromes
- NCT number
- NCT02867085
What you commit to
- Study type: Observational
- Participants enrolled: 297
- From 19 Jul 2017 to the primary completion date, 1 Aug 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of bilateral total hip replacement prior to study
- Control group only: diagnosis of MDS or AML prior to study
- Prior allogeneic stem cell transplantation
Other illness
- Dementia defined as MMSE score of \<24
- Active infection (HIV, hepatitis B or C, tuberculosis)
- Heart insufficiency NYHA III or IV or severe cardiac valve disease
Lab values
- Renal insufficiency with an eGFR \<30 mL/min
Other
- Liver cirrhosis Child-Pugh B or C
Who the study is looking for
- Age ≥60 years
- With known or suspected MDS (according WHO, \<20% blast count)
- Written informed consent
- Age ≥60 years
- Undergoing elective knee or hip replacement therapy
- Normal blood count (defined by Hb ♀ \>12 g/dL, ♂ \>13 g/dL; ANC \>1.8x10\^9/L; PLT \>100x10\^9/L)
- Written informed consent
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitätsklinikum Dresden Coordinator of this site? Confirm its status | Dresden | Germany | Unknown status |
| Universitatsklinikum Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.