NCT02980887Active, not recruiting
Pulmonary Vascular Disease Phenomics Program PVDOMICS
Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics (PVDOMICS)
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
It is recognized that patients with various forms of heart and lung disease exhibit varying degrees of pulmonary hypertension, pulmonary vascular remodeling, and right ventricular dysfunction. The genetic, molecular, and cellular processes driving these phenomena are not well understood. Rapid advances in high throughput omic methodology, combined with powerful bioinformatics and network biology capability, have created the opportunity to conduct studies that broadly search for homologies and differences across the spectrum of disease states associated with pulmonary hypertension, and determinants of the spectrum of right ventricular compensation that accompanies these conditions
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1195 (actual)
- First submitted
- 30 Nov 2016
- Start date
- Nov 2016
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- The Cleveland Clinic
- NCT number
- NCT02980887
What you commit to
- Study type: Observational
- Participants enrolled: 1195
- From Nov 2016 to the primary completion date, 31 Dec 2029
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent participation in any investigational drug study or other clinical trial
- Participant Level 2 (telephone visit):
Other illness
- Transplant other than heart or lung
- Transplant other than heart or lung
Other
- Dialysis dependent renal function; In the clinician's opinion, too ill to perform the protocol testing; Pregnant or nursing
- Longitudinal study:
- Participant Level 1 (clinic visit):
- In the clinician's opinion, too ill to perform L-PVDOMICS testing even if limited testing.
- Participants who withdrew from the parent PVDOMICS study
- Pregnant or nursing
- Participants who withdrew from the parent PVDOMICS study
- Participant Level 3 (medical chart review):
- \- Participants who withdrew from the parent PVDOMICS study
Who the study is looking for
- Patients ages \>18 years of age referred for right heart catheterization for further evaluation of known PVD or to be at risk for PVD due to established cardiac disease or pulmonary disease
- Able to perform complete diagnostic testing listed subsequently (cardiac catheterization, echo, exercise test, PFT's, ECG, chest CT, quality of life questionnaires, ventilation/perfusion scan, cardiac MRI, body composition bioimpedance, and sleep study)
- Subject signs informed consent to perform required testing for the protocol
- Any PH, comparators or control participant previously enrolled in the parent PVDOMICS protocol with a minimum of six months post-enrollment
- Dialysis dependent renal function since the parent study acceptable
Criteria the registry did not label
- Cross-sectional (parent) study:
Age in the registry: 18 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (7)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins University School Of Medicine Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Weill Cornell Medicine Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of Arizona Health Sciences Center Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| New York Medical College Coordinator of this site? Confirm its status | Valhalla | United States | Unknown status |
Related publications
- Pulmonary Artery Dilation on Chest CT Scan Across the Spectrum of Chronic Lung Disease.Chest · 2026 · PMID 42785424
- Endotypes of Vascular Health Predict Transplantation-Free Survival in Pulmonary Hypertension.J Am Heart Assoc · 2026 · PMID 42466490
- Phenotypic Characterization of Unclassified Pulmonary Hypertension.Circ Heart Fail · 2026 · PMID 42318624
This page is information, not medical advice. Discuss any trial with your doctor.