Tumor Growth Speed and Survival in Head and Neck Cancer Treated With Radiotherapy
Studies how fast head and neck cancer grows and survival in adults given radiation.
Plain-language title generated from the registry record
Registry title: Prognostic Impact of Tumor Growth Velocity in Head and Neck Squamous Cell Carcinoma Treated by Radio(Chemo)Therapy
Key facts
- Where
- Namur and Yvoir, BelgiumSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with head and neck squamous cell carcinoma who are chosen for radiotherapy or radiochemotherapy. It studies how fast the tumor grows.
- Age
- 18 Years and older
- Sex
- Men and women
- Disease stage
- Squamous cell carcinoma of the head and neck (T1 to T4): oral cavity, oropharynx, larynx or hypopharynx. The tumor must be visible on CT.
- Earlier treatment
- A team of doctors has chosen radiotherapy or radiochemotherapy as the treatment. People whose first treatment is surgery cannot join.
Main reasons for not taking part
- Cancer that has spread to other parts of the body (metastatic disease)
- Surgery as the first treatment
- Cannot have iodine contrast injection (anaphylaxis or kidney failure)
- Tumor not visible on CT
Read by machine on 12 November 2026.
Where in Belgium
- Clinique Ste-ElisabethNamur, BelgiumContact: Jean-Francois Daisne, MD,PhDNo longer taking part
- CHU Dinant GodinneYvoir, BelgiumContact: Sebastien Vandervorst, MD,PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre Hospitalier Universitaire UCLouvain Namur
- Trial code
- NCT02990936
- Record updated
- 3 October 2019
- Original description
The purpose of this study is to determine the impact of tumor growth velocity on the survival of patients with hea and neck squamous cell carcinoma treated by (chemo-)radiotherapy.Read full original descriptionShow less
Prognostic Impact of Tumor Growth Velocity in Head and Neck Squamous Cell Carcinoma Treated by Radio(Chemo)Therapy
The purpose of this study is to determine the impact of tumor growth velocity on the survival of patients with hea and neck squamous cell carcinoma treated by (chemo-)radiotherapy.
Patients with stages I to IV oropharyngeal primary squamous cell carcinoma (OPSCC) elected for radiotherapy or radiochemotherapy with curative intent will be selected. Tumor volume and number and size of pathological neck lymph nodes (small diameter > 1 cm) will be assessed on diagnostic CT-scan (DiCT) and treatment planning CT-scan (RtCT) using the summation of areas technique. Tumor progression and tumor doubling time will be calculated based on DiCT and RtCT. Tumor proliferation will be assessed on biopsy specimens by Ki67 immunohistochemistry and mitotic index. HPV status will be evaluated by PCR and p16 immunohistochemistry. Ulcerative or exophytic aspect will be noticed. Tumoral kinetics patterns will be correlated with disease free survival and overall survival of patients with HNSCC. These patterns will be compared to HPV status and proliferation markers in order to study their clinical signification [time frame: 5 years] and develop predictive markers of tumor progression for head and neck cancers.
Inclusion: clinical and anatomopathological diagnosis of a head and neck squamous cell carcinoma (T1 to T4) (oral cavity, oropharynx, larynx, hypopharynx); multidisciplinary decision for radiotherapy or concomitant radiochemotherapy eligibility.
Exclusion: primary surgical management; metastatic disease; contraindications to iodine contrast injection: anaphylaxis and renal insufficiency; tumor not visible on CT.