Following people with multiple sclerosis over many years to learn about their disease
Observes people with multiple sclerosis over many years to understand how the disease changes.
Plain-language title generated from the registry record
Registry title: Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
Key facts
- Where
- Pittsburgh, United StatesSee the site
Where in United States
- University of PittsburghPittsburgh, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pittsburgh
- Trial code
- NCT02994121
- Record updated
- 29 December 2025
- Original description
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.Read full original descriptionShow less
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Inclusion: Inclusion criteria for MS patients include:; Age 7 years or older; Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years); Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease; For healthy controls:; Age 7 years or older; Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years); No known personal history of multiple sclerosis or related disorders; No other chronic diseases; Family members, unrelated household controls, or controls from the general population could be eligible; There is no exclusion criteria.