Focal Radiotherapy Tested for Prostate Cancer That Returns After Treatment
Tests focused high-dose radiation for prostate cancer that has come back in adults.
Plain-language title generated from the registry record
Registry title: Focal Radiotherapy for Previously Treated Prostate Cancer Patients
Key facts
- Where
- St Leonards, AustraliaSee the site
Where in Australia
- Royal North Shore HospitalSt Leonards, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Royal North Shore Hospital
- Trial code
- NCT03073278
- Record updated
- 6 February 2026
- Original description
To examine the feasibility, safety and toxicity of focal stereotactic radiation treatment (SBRT) for locally recurrent prostate cancer.Read full original descriptionShow less
Phase I Feasibility Trial of Stereotactic Re-irradiation of Prostate Cancer Recurrence Within the Definitively Irradiated Prostate
To examine the feasibility, safety and toxicity of focal stereotactic radiation treatment (SBRT) for locally recurrent prostate cancer.
Inclusion: Men > 4yrs from external beam radiotherapy (EBRT) meeting the Phoenix definition of biochemical failure or men > 5yrs from EBRT if neo-adjuvant and/or adjuvant androgen deprivation therapy (ADT) also used; Recurrence localised to less than 1 lobe of prostate on both PMSA and multi-parametric MRI (less than equal to cT2a); Recurrence must be biopsy proven, with positive biopsies limited to the PET and MRI suspicious region; Life expectancy at least 10yrs from time of SBRT; PSA < 10.
Exclusion: Grade 3 or more toxicity from previous EBRT; GS 8,9 or 10 disease previously (relative - consider if decent disease free interval); Recurrence in immediate proximity to rectum (unless able to have hydrogel); Contra-indicated for fiducial insertion.