INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients
Key facts
- Where
- Montreal and Ottawa, CanadaSee the 2 sites
Where in Canada
- McGill University Health CenterMontreal, CanadaTaking people
- The Ottawa HospitalOttawa, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Dr. J. Werier
- Trial code
- NCT03175718
- Record updated
- 2 March 2026
- Original description
Project Summary - Aggressive soft tissue cancers are commonly treated with radiation followed by surgery. These wounds have a very high rate of wound complications and infection (30%), resulting in more surgeries, longer hospital stays and complex nursing care. Previous research shows that negative pressure (vacuum) dressings applied to the incision at the end of surgery can reduce these complications. The Investigator and his team across Canada will perform a clinical trial comparing standard dressings to these vacuum dressings. The results of this study have the potential to immediately improve the quality of life of soft tissue cancer patients. It can also decrease the amount of time required in hospital and reduce the cost to the Canadian healthcare system.Read full original descriptionShow less
The Effect of INPWT on Wound Complications and Clinical Outcomes Following Lower Extremity Sarcoma Surgery in Patients Treated With Preoperative Radiation Therapy: A Multicentre Randomized Controlled Trial
Project Summary - Aggressive soft tissue cancers are commonly treated with radiation followed by surgery. These wounds have a very high rate of wound complications and infection (30%), resulting in more surgeries, longer hospital stays and complex nursing care. Previous research shows that negative pressure (vacuum) dressings applied to the incision at the end of surgery can reduce these complications. The Investigator and his team across Canada will perform a clinical trial comparing standard dressings to these vacuum dressings. The results of this study have the potential to immediately improve the quality of life of soft tissue cancer patients. It can also decrease the amount of time required in hospital and reduce the cost to the Canadian healthcare system.
Inclusion: Patients 18 years of age and older and are able to provide written consent; Patients with lower extremity soft tissue sarcoma confirmed by tissue pathology.Each patient must have local cross sectional imaging (CT or MRI) and a staging CT chest; Patients eligible for treatment with preoperative radiation therapy followed by limb salvage surgery; Patients for which a primary closure must be attained at the time of surgery; Patient must be available for postoperative follow-up at the treating center.
Exclusion: Patients with a benign disease or with prior radiation to the anatomic region in the remote past (not associated with current treatment radiation plans); Patients who underwent surgical amputation; Patients who have an allergy or sensitivity to adhesive dressings; Patients who are less than 18 years of age; Patients in which primary closure was not achieved (including free flaps and split thickness skin grafts); Patients with a life expectancy less than 120 days.