Long-term follow-up of fatty liver disease in Chinese children
Follows children with fatty liver disease to study how their liver condition develops over time.
Plain-language title generated from the registry record
Registry title: Nonalcoholic Steatohepatitis in Chinese Children
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 18 years old?
Source: NCT03190538, who can take part
Where in China
- Children's Liver Disease Center, 302 HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Humanity and Health Research Centre
- Trial code
- NCT03190538
- Record updated
- 29 July 2026
- Original description
Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality.Read full original descriptionShow less
Nonalcoholic Steatohepatitis in Chinese Children: a Long Term Follow-up
Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality.
A growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.
Inclusion: age 1-18 with biopsy-proven NAFLD; Alcohol consumption less than 20g/day and 10g/day for boys and girls respectively.
Exclusion: with liver impaired by drugs; with viral hepatitis, e.g. HBV, HCV; with a1-anti-trypsin disease; with autoimmune hepatitis; with Wilson disease.