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Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome

Key facts

Who runs it
Göteborg University
Where
Netherlands, Spain, and Sweden3 sites in 3 countriesChoose a country to see its sites
Trial code
Status
Active, not recruiting
People taking part
72 people, planned
Started
1 May 2017
Ended
31 Dec 2025
Type of study
Observational, 2 groups
Record updated
6 April 2025

Who can take part

Age
18 years to 65 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 18 criteriaShow less

Who can take part

  • Male and female patients with Cushing syndrome (CS) caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma
  • Age between 18 and 65 years

Who cannot take part

  • Previous history of major psychiatric disorder (not related to CS)
  • Contraindication for MRI (Presence of medical implants, metal in the body, claustrophobia)
  • Neurological disorders affecting the central nervous system
  • Active malignancy or any treatment for malignancy during the last 2 years
  • Heart failure (NYHC II-IV)
  • Severe respiratory insufficiency
  • Any other illness that significantly affects the patients cognitive function according to the investigators opinion
  • Severely impaired hepatic function (alanine transaminase and/or aspartate transaminase concentrations two times the upper limit of normal or above)
  • Severely impaired renal function (serum- creatinine >150 µmol/L or glomerular filtration rate <45 ml/min)
  • CS caused by ectopic ACTH producing tumours
  • CS caused by adrenocortical carcinoma
  • Pseudo CS
  • Subclinical CS
  • Exogenous CS
  • High alcohol consumption (more than 14 units of alcohol per week)
  • Pregnancy or breast feeding

This trial has no sites in United States.

It has sites in 3 countries. Choose a country to see its sites.

About the trial

What the trial wants to find out

This is a prospective, multi-center, case-control study where neurocognitive function will be evaluated in 36 patients with Cushing syndrome (CS) and 36 controls matched for age, gender and education.

The 2 groups in the trial

  • Cushing syndrome

    Male and female patients with Cushing syndrome caused by ACTH-producing pituitary adenoma or cortisol producing adrenal adenoma

  • Controls

    Healthy controls matched for age, gender, and educational level

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
The Etiology and Extent of Impaired Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome - Prospective Studies
Record updated
6 April 2025