Comparing One Versus Several Artery Grafts in Bypass Heart Surgery
Tests using one artery graft or several in bypass surgery for coronary artery disease.
Plain-language title generated from the registry record
Registry title: Randomization of Single vs Multiple Arterial Grafts
Key facts
- Where
- Duisburg, Düsseldorf, Erlangen, Giessen, Göttingen, Jena, Leipzig, Oeynhausen, Stuttgart, and Trier, GermanySee the 11 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having a first, planned heart bypass operation (CABG) alone. It compares one artery graft with two or more artery grafts.
- Age
- 18 to 70 years
- Sex
- All sexes can join.
- Disease stage
- Coronary artery disease with disease of the left main artery and/or the left anterior descending and circumflex arteries, with or without right coronary artery disease; first bypass surgery alone.
- Earlier treatment
- People who have had earlier heart surgery cannot join.
Main reasons for not taking part
- Emergency operation
- Heart attack in progress within 48 hours of surgery
- Left ventricular ejection fraction below 35%
- Any other heart or non-heart procedure at the same time
- Serious organ failure, cancer or another illness that cuts life expectancy to less than 5 years
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT03217006, who can take part
Where in Germany
- Duisburg Heart CenterDuisburg, GermanyContact: Jochen BörgermannTaking people
- Essen UniversityDuisburg, GermanyContact: Matthias Klaus ThielmannTaking people
- Düsseldorf UniversityDüsseldorf, GermanyContact: Alexander AssmannTaking people
- University Hospital ErlangenErlangen, GermanyContact: Ehab NoohTaking people
- Giessen HospitalGiessen, GermanyContact: Andreas BoeningTaking people
- University Medical Center of GoettingenGöttingen, GermanyContact: Mario Gaudino, MDEnrolling by invitation
- Jena University HospitalJena, GermanyContact: Torsten DoenstTaking people
- Heart Center (Herzzentrum)Leipzig, GermanyContact: Michael BorgerTaking people
- HDZ NRW BadOeynhausen, GermanyContact: Kavous Haikim- MeibodiTaking people
- Robert-Bosch-HospitalStuttgart, GermanyContact: Marc AlbertTaking people
- Krankenhaus der Barmherzigen Brüder TrierTrier, GermanyContact: Terrence John DonovanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Weill Medical College of Cornell University
- Trial code
- NCT03217006
- Record updated
- 20 August 2026
- Original description
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any stroke, post discharge myocardial infarction and/or repeat revascularization. The secondary hypothesis is that in patients undergoing primary isolated non-emergent CABG, the use of two or more arterial grafts compared to a single arterial graft is associated with improved survival.Read full original descriptionShow less
Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: the ROMA Trial
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a reduction in the composite outcome of death from any cause, any stroke, post discharge myocardial infarction and/or repeat revascularization. The secondary hypothesis is that in patients undergoing primary isolated non-emergent CABG, the use of two or more arterial grafts compared to a single arterial graft is associated with improved survival.
Prospective event-driven unblinded randomized multicenter trial of at least 4,300 subjects enrolled in at least 25 international centers. Patients will be randomized to a single arterial graft (SAG) or multiple arterial grafts (MAG). Patients will be randomized in a 1:1 fashion between the two groups. Permuted block randomization with random blocks stratified by the center and the type of second arterial graft will be used to provide treatment distribution in equal proportion.
Inclusion: Primary isolated CABG patients with disease of the left main coronary artery and/or of the left anterior descending and the circumflex coronary system with or without disease of the right coronary artery.
Exclusion: Any concomitant cardiac or non-cardiac procedure; Previous cardiac surgery; Evolving myocardial infarction within 48 hours of surgery; Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure), cancer or any co-morbidity that reduce life expectancy to less than 5 years; Left ventricular ejection fraction of < 35%; Age > 70 years; Single graft; Emergency operation; Inability to use the saphenous vein or to use both radial and right internal thoracic arteries; Anticipated need for coronary thrombo-endarterectomy; Planned hybrid revascularization.