Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis

Who can take part

• Age: 40-80 years (inclusive)
• Gender: male or female (non-pregnant)
• Fluent in written and spoken English
• Patients capable of giving informed consent
• Primary diagnosis of osteoporosis that will be treated with either Forteo® to induce bone anabolism or Prolia® by the study investigator as part of patient's standard of care treatment
• Symptomatic, medial compartment knee OA with a Kellgren-Lawrence (K-L) score between II-III (documented in the medical record by previously collected knee series radiography). Radiographs to be performed within past two years

Who cannot take part

• Depression (currently taking home medication)
• Use of immunosuppressants, chemotherapy, or radiotherapy
• Cognitive impairment
• History of hyperparathyroidism, hypercalcemia, current/recent renal stones, or malignancy
• History of inflammatory disease (colitis, rheumatoid arthritis, psoriasis, lupus, scleroderma, spondylitis)
• Age < 40 or >80 years
• Pregnancy
• Non-English speaking persons
• BMI, angular deformity and K-L score of the contralateral knee (if the OA is bilateral) will be noted as covariates