Eye Imaging to Study Retinal Changes in Brain Diseases
Uses eye scans to study the retina in people with memory or brain diseases.
Plain-language title generated from the registry record
Registry title: Retinal Imaging in Neurodegenerative Disease
Key facts
- Where
- Durham, United StatesSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a brain or nerve disease that damages cells over time, and also adults without one. Everyone has eye scans.
- Age
- 18 years or older.
- Sex
- All sexes can join.
- Disease stage
- Adults with a neurodegenerative disease (such as MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD, other neurodegenerations, or Down Syndrome), or adults without one.
Main reasons for not taking part
- Cannot cooperate with or finish the testing
- Other nerve-related or age-related eye conditions that would affect the eye images
- Eyes that had eye surgery other than cataract surgery
Read by machine on 12 November 2026.
Where in United States
- Duke University Medical CenterDurham, United StatesContact: Sharon Fekrat, MD FACS FASRSTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Duke University
- Trial code
- NCT03233646
- Record updated
- 4 February 2026
- Original description
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.Read full original descriptionShow less
Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Inclusion: Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome); Adults without neurodegenerative disease.
Exclusion: Eyes that have had intraocular surgery, other than cataract surgery; If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study; Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.