Testing a blood-flow-lowering drug's effect on breathing during sleep
Tests a drug that lowers brain blood flow in adults with sleep apnea.
Plain-language title generated from the registry record
Registry title: Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Key facts
- Where
- Calgary, CanadaSee the site
- Phase
- Phase 1/2
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for healthy adults aged 18 - 45 who have lived in Calgary for the past year and have no medical condition.
- Age
- 18 - 45 years
- Sex
- All sexes can join.
- Earlier treatment
- People must not be taking any blood pressure medications.
Main reasons for not taking part
- Brain blood vessel, heart, lung, kidney or metabolic diseases
- Bleeding disorders or upper stomach and gut diseases such as peptic ulcer
- Pregnancy, obesity or sleep-disordered breathing
- Drug allergy to non-steroidal anti-inflammatories
- Currently smoking
This trial only enrols healthy participants. The registry sentence this rests on: Healthy adults
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT03255408, who can take part
Where in Canada
- University Of CalgaryCalgary, CanadaContact: Chair, Conjoint Ethics BoardTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Calgary
- Trial code
- NCT03255408
- Record updated
- 1 May 2026
- Original description
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).Read full original descriptionShow less
Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
Inclusion: Healthy adults; 18 - 45 years of age; Living in Calgary for the past one year; Have no medical condition or should not be taking any blood pressure medications; The participant should not be lactose intolerant.
Exclusion: Cerebrovascular, cardio-respiratory, renal and metabolic diseases; Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease; Drug allergies to non-steroidal anti-inflammatories; Pregnancy, obese and sleep-disordered breathing; Currently smoking.