Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
Key facts
- Where
- Bordeaux, Caen, Limoges, Nancy, Nantes, Paris, Rennes, Suresnes, Toulon, and Tours, FranceSee the 12 sites
Where in France
- CHU de BordeauxBordeaux, FranceTaking people
- CHU CaenCaen, FranceTaking people
- CHU LimogesLimoges, FranceTaking people
- CHRU de NancyNancy, FranceTaking people
- CHU de NantesNantes, FranceTaking people
- Centre Hospitalier Sainte-AnneParis, FranceTaking people
- Fondation Ophtalmologique A. de RothschildParis, FranceTaking people
- Hôpital Lariboisière AP-HPParis, FranceTaking people
- CHU de RennesRennes, FranceNo longer taking part
- Hopital FochSuresnes, FranceTaking people
- Hopital d instruction des armees sainte anneToulon, FranceTaking people
- CHRU ToursTours, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondation Ophtalmologique Adolphe de Rothschild
- Trial code
- NCT03268668
- Record updated
- 20 January 2026
- Original description
The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes. This treatment option also opens up a new field of research, making possible the analysis of the clot responsible for intracranial occlusion. Indeed, in about 30% of the cases, the thrombectomy procedure makes it possible to retrieve either partially or completely the clot. Previous studies have analyzed the correlation between the composition of the thrombus and the etiology of stroke. Their discordant results do not yet make it possible to distinguish a particular profile of thrombus according to etiology. Other studies have shown a correlation between the proportion of red blood cells in a thrombus and the likelihood that it is visible in MRI or cerebral scanning. More recently, one study has demonstrated a correlation between the presence of lymphocytes in the thrombus and an atheromatous etiology.Read full original descriptionShow less
The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes. This treatment option also opens up a new field of research, making possible the analysis of the clot responsible for intracranial occlusion. Indeed, in about 30% of the cases, the thrombectomy procedure makes it possible to retrieve either partially or completely the clot. Previous studies have analyzed the correlation between the composition of the thrombus and the etiology of stroke. Their discordant results do not yet make it possible to distinguish a particular profile of thrombus according to etiology. Other studies have shown a correlation between the proportion of red blood cells in a thrombus and the likelihood that it is visible in MRI or cerebral scanning. More recently, one study has demonstrated a correlation between the presence of lymphocytes in the thrombus and an atheromatous etiology.
The main limitations of these studies are the small number of patients included, the high variability of conservation protocols and the absence of plasma data, which does not allow for research on the correlation between clot composition and plasma biomarkers.
Inclusion: Patients aged 18 years and older; Presenting with cerebral infarction following arterial occlusion; Treated for mechanical thrombectomy (whether performed or not); Free, informed, and express consent of the patient or their relatives (emergency inclusion procedure); For retrospective patients: thrombus already collected (according to the center's usual practice or for another research project).
Exclusion: Patient benefiting from a legal protection measure; Pregnant or breastfeeding woman.