NCT03272230Completed
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System in Healthy Subject and Patient With Cerebral Disease
Source: ClinicalTrials.gov · Last updated 20 May 2026
Brief summary (registry, in English)
Apathy is defined as a quantitative reduction in voluntary and goal-directed behavior. To address this, the investigators propose an ethological approach to assess apathy objectively and quantitatively by observing patients in real-life situations. The ECOCAPTURE paradigm involves a structured, multi-step scenario conducted in a functional exploration platform. This platform is equipped with an advanced data acquisition system integrating video recordings and sensors to precisely monitor and analyze participants' behavior. Primary objective: Develop a diagnostic tool for apathy using metrics derived from video recordings and sensor data. This tool aims to provide objective measures to identify and quantify apathy. Secondary Objectives: * Validation of ICM\_APATHY\_TASKS: This novel experimental task is designed to evaluate three primary mechanisms thought to underlie apathy: Motivation, Cognitive inertia (difficulty initiating tasks), The interaction between motivation and action execution. * Identification of the pathophysiological mechanisms of apathy by investigate the cognitive, behavioral, neural, and neurohormonal underpinnings of apathy. This will enable the classification of apathetic patients into subtypes (or several forms of apathy) based on the dominant mechanisms and provide insights into which processes best explain apathy in individual cases. This innovative framework aims to deepen the understanding of apathy, improve diagnostic precision, and pave the way for tailored interventions.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 66 (actual)
- First submitted
- 3 Aug 2017
- Start date
- 6 Sept 2017
- Primary completion date
- 8 Dec 2023
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Diseases
- Frontotemporal dementia, Depression
- NCT number
- NCT03272230
What you commit to
- Study type: Interventional
- Participants enrolled: 66
- From 6 Sept 2017 to the primary completion date, 8 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- MRI Contraindications: Standard contraindications to magnetic resonance imaging (e.g., pacemaker, metallic implants, claustrophobia).
Other
- Cognitive Barriers: Inability to comprehend study instructions.
- Legal Restrictions: Individuals referenced in Articles L.1121-5 to L.1121-8 and L.1122-12 of the French Public Health Code.
Who the study is looking for
- Eligibility Criteria for All Groups:
- Demonstrates the ability to provide informed consent for participation in the study.
- Capable of understanding study instructions and performing cognitive tasks as required.
- Enrolled in a valid health insurance plan.
- Eligibility Criteria for Patients:
- Mini-Mental State Examination (MMSE): Score ≥ 17.
- Medical History: Absence of any other neurological or psychiatric conditions.
- Caregiver Requirement: Must have a caregiver present.
- Patient Groups:
- Diagnosed with behavioral variant frontotemporal dementia (bvFTD) based on the Rascovsky criteria (Rascovsky et al., 2011).
- Diagnosed with Major Depressive Disorder (MDD) according to DSM-IV criteria.
- Eligibility Criteria for Healthy Age-, Sex-, and Education-Matched Controls:
- Mini-Mental State Examination (MMSE): Score \> 27.
- Medical History: No history of neurological or psychiatric disorders.
Age in the registry: 40 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Paris Brain Institute / ICM / Pitié-Salpêtrière Hospital AP-HP / CIC Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.