Registry following pregnant women with autoimmune and rheumatic diseases
Tracks pregnancy health in women with lupus, arthritis and related autoimmune conditions.
Plain-language title generated from the registry record
Registry title: Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Key facts
- Where
- Durham, United StatesSee the site
Where in United States
- Duke UniversityDurham, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Duke University
- Trial code
- NCT03276923
- Record updated
- 8 January 2026
- Original description
This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases.Read full original descriptionShow less
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases.
The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy.
Prior studies demonstrate the importance of increase inflammation prior to and during pregnancy on these outcomes. The future research will seek to better define these risk factors and to identify ways to may improve them.
Inclusion: Desire for pregnancy within 6 months or currently pregnant; Women with systemic autoimmune disease, including:; Lupus (systemic lupus erythematosus or cutaneous lupus); Antiphospholipid Syndrome or positive antiphospholipid antibodies; Rheumatoid Arthritis; Scleroderma (systemic sclerosis); Sjogren's Syndrome; Inflammatory Arthritis (including Psoriatic Arthritis and Ankylosing Spondylitis); Undifferentiated Connective Tissue Disease (UCTD); Vasculitis; Myositis (Polymyositis or Dermatomyositis); Positive Ro/SSA or La/SSB antibodies.
Exclusion: Unable to speak English; Unable to provide informed consent; Unable to travel to Duke University for follow-up visits.