Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
Key facts
- Where
- Hong Kong, Hong KongSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 85 years old?
Source: NCT03291652, who can take part
Where in Hong Kong
- Chinese University of Hong KongHong Kong, Hong KongTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chinese University of Hong Kong
- Trial code
- NCT03291652
- Record updated
- 24 February 2026
- Original description
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).Read full original descriptionShow less
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
Inclusion: Inclusion Criteria for the Symptomatic Group:; Patient is 30 to 85 years of age, inclusive; Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD; Patient who has no contra-indication for the proposed imaging tests; Patient understands the purpose and requirements of the study, and has provided an informed consent; Inclusion Criteria for the Asymptomatic Group:; Patient is 30 to 85 years of age, inclusive; Patient who has a high-grade (>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence; Patient has no MES detected on TCD examination; Patient who has no contra-indication for the proposed imaging tests; Patient understands the purpose and requirements of the study, and has provided an informed consent.
Exclusion: Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc; A medical condition that would not allow the patient to adhere to the protocol or complete the study; Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets <100 x 109/L), coagulopathy (INR >1.5); Subject who meets one or more of the following criteria cannot be recruited in the study:; A tandem stenosis >50% at proximal internal carotid artery.