Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
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- Who runs it
- Montreal Heart Institute
- Trial code
- NCT03303612
- Record updated
- 14 October 2026
- Original description
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization, and death in patients in patients with new of left bundle branch block following transcatheter aortic valve implantation (TAVI).Read full original descriptionShow less
Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach in Patients With a New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation (TAVI) a Bayesian Randomized Trial (COME-TAVI)
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization, and death in patients in patients with new of left bundle branch block following transcatheter aortic valve implantation (TAVI).
Inclusion: Age ≥18 years; Informed consent to participate; Persistent new-onset LBBB after TAVI implantation (i.e. present at day 2).
Exclusion: Prior pacemaker or implantable cardioverter-defibrillator; Pre-existing right bundle branch block (RBBB) or LBBB (i.e., prior to TAVI); Class I or IIA indication for PPM implantation according to management guidelines.