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Taking people in United StatesNo phase

Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study

Key facts

Who runs it
Indiana University
Where
Indianapolis, United StatesSee the 2 sites
Trial code
Status
Recruiting
People taking part
10 people, planned
Started
Nov 2016
Expected to end
31 Dec 2026
Type of study
Observational
Treatments tested
  • endoflip
Record updated
24 November 2025

Who can take part

Age
18 years to 65 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • Presence of eosinophilia on esophageal biopsy, defined as a peak count of > 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)

Who cannot take part

  • Secondary causes of esophageal eosinophilia has been excluded, such as eosinophilic GI diseases, celiac disease, Crohn's disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease
  • History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)
  • Age < 18 or > 65 years
  • Contraindication for biopsy, such as presence of esophageal varices, coagulopathy
  • Pregnancy
  • Prisoners

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 65 years old?

Where in United States

  • Indiana UniversityIndianapolis, United StatesContact: Maureen SchillingTaking people
  • Indiana University Health University HospitalIndianapolis, United StatesContact: Maureen SchillingTaking people

About the trial

What the trial wants to find out

This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.

The group in the trial

  • Eosinophilic Esophagitis patients

    PPI treatment

    Treatment: endoflip

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Fit questions
Built from NCT03312686, who can take part
Record updated
24 November 2025