Improving Measurement and Treatment of Post-stroke Neglect
Key facts
- Where
- Pittsburgh, United StatesSee the site
Where in United States
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PAPittsburgh, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT03317860
- Record updated
- 2 October 2026
- Original description
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.Read full original descriptionShow less
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial direct current stimulation) for individuals with neglect. This study will also determine whether items from various neglect assessments can be combined to establish a more comprehensive neglect measure.
Inclusion: Ischemic or hemorrhagic stroke 3 months post stroke; Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60; Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS); Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score <18).
Exclusion: History of cortical hemorrhagic stroke; Presence of any MRI, TMS, tDCS risk factors including:; history of seizures; history of brain tumor; hardware in skull or spine (e.g. coils, clips); implantable medical device (e.g. pacemaker); metal in body (not compatible with MRI); pregnancy; Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2); Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, Memorandum of Understanding (MOU) approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study; Severe spasticity (Modified Ashworth Scale score 3).