Registry Platform Urologic Cancer
Key facts
- Where
- Multiple Locations, GermanySee the site
Where in Germany
- Multiple sites, GermanyMultiple Locations, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- iOMEDICO AG
- Trial code
- NCT03374267
- Record updated
- 5 November 2026
- Original description
The purpose of the project is to set up a national, prospective, longitudinal, multicenter cohort study with associated satellites, a tumor registry platform, to document uniform data on characteristics, molecular diagnostics, treatment and course of disease, to collect patient-reported outcomes and to establish a decentralized biobank for patients with advanced renal cell carcinoma or urothelial cancer in Germany.Read full original descriptionShow less
Clinical Research Platform On Urologic Cancer Treatment And Outcome (Registry Platform Urologic Cancer; CARAT)
The purpose of the project is to set up a national, prospective, longitudinal, multicenter cohort study with associated satellites, a tumor registry platform, to document uniform data on characteristics, molecular diagnostics, treatment and course of disease, to collect patient-reported outcomes and to establish a decentralized biobank for patients with advanced renal cell carcinoma or urothelial cancer in Germany.
Inclusion: Cohorts aRCC and aUBC (prospective); Female and male patients with aRCC or aUBC (locally advanced, inoperable or metastatic); Patients at start of their first-line systemic treatment for aRCC or aUBC; Written informed consent; Patients participating in the PRO module: signing of in-formed consent form and completion of baseline questionnaire before start of initial systemic treatment; Patients not participating in the PRO module: within twelve weeks after start of systemic first-line for aRCC or aUBC; Age ≥ 18 years; Cohort High-risk MIUC (prospective and retrospective); Histologically proven muscle-invasive urothelial carcinoma (MIUC) of the lower or upper urinary tract (ICD-10 C65, C66, C67.x, C68.x). Mixed histologies are allowed (main compo-nent must be urothelial carcinoma, with minor variants accept-ed); Radical surgery (e.g., radical cystectomy, nephroureterecto-my) between October 1, 2021 and October 31, 2024; High-risk of recurrence, defined as follows: Post-operative, pathological tumor status; ypT2-ypT4 and/or ypN+ and without clinically detectable metastases (M0) at cystectomy for patients with prior neo-adjuvant chemotherapy or; pT3-pT4 and/or pN+ and without clinically detectable me-tastases (M0) at cystectomy for patients without prior neo-adjuvant chemotherapy; Age ≥ 18 years at the time of surgery; Written informed consent (only if patient is alive at time of data entry; not applicable for inclusion of deceased patients' data); Cohort MIBC (prospective); Diagnosis of MIBC (muscle-invasive bladder cancer; ICD-10 C67.x; cT2-T4aN0M0 or T1-T4aN1M0); Histologically proven muscle-invasive urothelial carcinoma. Mixed histologies are allowed (main component must be urothelial histology, with minor variants accepted); Age ≥ 18 years at the time of diagnosis; Written informed consent within 15 weeks from diagnosis of MIBC.
Exclusion: Patients with prior systemic therapy for aRCC or aUBC; Partial cystectomy or partial nephrectomy of the primary tumor as definitive therapy; Metastatic disease (M1) at the time of surgery; Cohort MIBC (prospective); Cohorts aRCC and aUBC (prospective); No systemic treatment for aRCC or aUBC; Cohort High-risk MIUC (prospective and retrospective); Clinically detectable metastases (M1) at the time of diagnosis; Treatment in palliative intention (for tumors considered inoperable).