Studying genes linked to several types of glaucoma
Collects blood samples from people with glaucoma to look for genetic risk factors.
Plain-language title generated from the registry record
Registry title: Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
Key facts
- Where
- Vienna, AustriaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 21 and 105 years old?
Source: NCT03423758, who can take part
Where in Austria
- Department of Clinical Pharmacology, Medical University of ViennaVienna, AustriaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of Vienna
- Trial code
- NCT03423758
- Record updated
- 23 May 2025
- Original description
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG). The aim of the present prospective, multi-center, case-control study is to identify susceptibility genes/loci for PXF, PACG and POAG using a whole genome association (WGA) approach.Read full original descriptionShow less
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma
There is increasing evidence that there are genetic risk factors for several forms of glaucoma, such as glaucoma caused by pseudoexfoliation syndrome (PXF) ,primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG). The aim of the present prospective, multi-center, case-control study is to identify susceptibility genes/loci for PXF, PACG and POAG using a whole genome association (WGA) approach.
Inclusion: For patients with PXF:; Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history; Informed consent; Age 50 years or more; For patients with PACG:; Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history; Informed consent; Age 21 years or more; For healthy controls:; No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history; No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history; Age more than 60 years; Informed consent; For patients with POAG:; Patients with confirmed primary open angle glaucoma (POAG); No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma; Informed consent; Age 30 or more.
Exclusion: Active or history of uveitis; Secondary angle closure such as neovascular glaucoma or uveitis/inflammatory eye disease; Patients and subjects will be excluded if one or more of the following criteria apply:; Neovascular glaucoma; Inability to give informed consent.